Post-stroke complications are a major cause of mortality in stroke patients. These complications include psychiatric and cognitive impairments, pulmonary and urinary infections, cardiovascular deficits, metabolic disorders, etc. In contrast to the widely explored local neurovascular deficits, the cellular and molecular mechanisms involved in multiple post-stroke complications have scarcely been investigated. Diagnosis and treatment of these complications tend to be missed or delayed due to inadequate understanding. A series of complicated factors may give rise to these lethal and disabling complications, such as disruption in neural circuits, stroke-induced immunodepression syndrome, autonomic disturbances, and other pathological alterations. Still, the underlying mechanisms remain to be elucidated.
In this Research Topic, we aim to provide a further understanding of how the above-mentioned pathological factors contribute to the development of post-stroke complications, thereby improving functional recovery and life expectancy in stroke patients. Post-stroke complications include recurrent stroke, residual motor disability, neuropsychological deficits, infections, cardiopathy, vascular embolism, and other disorders induced by a cerebrovascular accident. In addition to in vivo and in vitro studies, clinical observational and interventional studies investigating biomarker assessment and intervention strategies are encouraged. Manuscripts consisting of bioinformatics and computational analyses of public genetic, transcriptomic, or clinical databases with constructive suggestions for early diagnosis and interventions are welcome. This Research Topic will not consider traditional Chinese medicine-related articles for publication.
We welcome Original Research, Clinical Trial, GWAS/Mendelian Randomization Study, Review, Mini-Review, Perspective, Clinical Trial, and Opinion articles from human and animal research focusing on, but not limited to, the following themes:
- Novel cellular and molecular mechanisms contributing to post-stroke complications
- The pathogenic crosstalk between local cerebral damage and peripheral tissues/organs
- Biomarkers and predictive factors/systems/algorithms associated with the incidence, severity, and clinical outcomes of stroke-induced complications
- Applications of the latest neuroimaging and other techniques to comprehensively assess and diagnose stroke-induced complications
- Clinical courses and early management strategies for post-stroke complications
- Expert comments, consensus, or guidelines for diagnosis and treatment of post-stroke complications
Post-stroke complications are a major cause of mortality in stroke patients. These complications include psychiatric and cognitive impairments, pulmonary and urinary infections, cardiovascular deficits, metabolic disorders, etc. In contrast to the widely explored local neurovascular deficits, the cellular and molecular mechanisms involved in multiple post-stroke complications have scarcely been investigated. Diagnosis and treatment of these complications tend to be missed or delayed due to inadequate understanding. A series of complicated factors may give rise to these lethal and disabling complications, such as disruption in neural circuits, stroke-induced immunodepression syndrome, autonomic disturbances, and other pathological alterations. Still, the underlying mechanisms remain to be elucidated.
In this Research Topic, we aim to provide a further understanding of how the above-mentioned pathological factors contribute to the development of post-stroke complications, thereby improving functional recovery and life expectancy in stroke patients. Post-stroke complications include recurrent stroke, residual motor disability, neuropsychological deficits, infections, cardiopathy, vascular embolism, and other disorders induced by a cerebrovascular accident. In addition to in vivo and in vitro studies, clinical observational and interventional studies investigating biomarker assessment and intervention strategies are encouraged. Manuscripts consisting of bioinformatics and computational analyses of public genetic, transcriptomic, or clinical databases with constructive suggestions for early diagnosis and interventions are welcome. This Research Topic will not consider traditional Chinese medicine-related articles for publication.
We welcome Original Research, Clinical Trial, GWAS/Mendelian Randomization Study, Review, Mini-Review, Perspective, Clinical Trial, and Opinion articles from human and animal research focusing on, but not limited to, the following themes:
- Novel cellular and molecular mechanisms contributing to post-stroke complications
- The pathogenic crosstalk between local cerebral damage and peripheral tissues/organs
- Biomarkers and predictive factors/systems/algorithms associated with the incidence, severity, and clinical outcomes of stroke-induced complications
- Applications of the latest neuroimaging and other techniques to comprehensively assess and diagnose stroke-induced complications
- Clinical courses and early management strategies for post-stroke complications
- Expert comments, consensus, or guidelines for diagnosis and treatment of post-stroke complications
