Marine and soil-derived Streptomyces sp. can produce a wide range of compounds with diverse bioactivities such as antitumor, antibacterial, and neuroprotective properties. However, the biosynthetic pathways of some novel bioactive compounds remain poorly understood. Meanwhile, the low yield limits the biomedical applications of some of the bioactive compounds. Thus, improving the yield of these Streptomyces sp.-derived compounds is critical to promote their future application. Genetic engineering techniques such as gene knockout, overexpression, and transcriptional activation can be used to increase the titers of these bioactive compounds.
In this Research Topic, we aim to discover novel compounds with diverse biological activities that have great potential in the biomedical industry. We are also interested in the development of novel biosynthetic approaches to increase the yield of bioactive compounds in Streptomyces sp. from marine and soil sources. In addition, the identification of novel bioactive compounds via biosynthetic strategies and transcriptional activation is encouraging for our Research Topic.
Subtopics, particularly of interest, are:
1) The discovery of bioactive compounds with medicinal potential derived from marine or soil Streptomyces sp., as well as the underlying bioactive mechanism;
2) Genome mining strategies to explore novel bioactive compounds from Streptomyces sp. via heterologous expression;
3) Overexpression of global regulators or specific regulators in Streptomyces sp. to increase the yield of target compounds or to discover new compounds;
4) The deletion of regulator or tailoring enzyme genes by gene knockout to increase the yield of target bioactive compounds or the exploitation of novel compounds.
Marine and soil-derived Streptomyces sp. can produce a wide range of compounds with diverse bioactivities such as antitumor, antibacterial, and neuroprotective properties. However, the biosynthetic pathways of some novel bioactive compounds remain poorly understood. Meanwhile, the low yield limits the biomedical applications of some of the bioactive compounds. Thus, improving the yield of these Streptomyces sp.-derived compounds is critical to promote their future application. Genetic engineering techniques such as gene knockout, overexpression, and transcriptional activation can be used to increase the titers of these bioactive compounds.
In this Research Topic, we aim to discover novel compounds with diverse biological activities that have great potential in the biomedical industry. We are also interested in the development of novel biosynthetic approaches to increase the yield of bioactive compounds in Streptomyces sp. from marine and soil sources. In addition, the identification of novel bioactive compounds via biosynthetic strategies and transcriptional activation is encouraging for our Research Topic.
Subtopics, particularly of interest, are:
1) The discovery of bioactive compounds with medicinal potential derived from marine or soil Streptomyces sp., as well as the underlying bioactive mechanism;
2) Genome mining strategies to explore novel bioactive compounds from Streptomyces sp. via heterologous expression;
3) Overexpression of global regulators or specific regulators in Streptomyces sp. to increase the yield of target compounds or to discover new compounds;
4) The deletion of regulator or tailoring enzyme genes by gene knockout to increase the yield of target bioactive compounds or the exploitation of novel compounds.