Respiratory diseases, such as COVID-19, pneumonia, asthma, chronic obstructive pulmonary disease, and lung cancer etc., are leading causes of death and disability in the world. With the development of sequencing technology, the critical roles of the respiratory microbiome in health and disease have been understood. As we know, a diverse and dynamic community of microbiome colonize on the inter-surface of the respiratory system. However, compared to gut ecosystem, less studies focus on the respiratory microbiome and its roles in health and disease. Although changed respiratory microbiome is associated with specific disease and host inflammation, more studies need to be conducted to broadly investigate the importance of the respiratory microbiome in health and disease.
As studies in the respiratory microbiome and its roles in health and disease continues to grow, several fundamental questions and challenges arise. They are: how the factors (i.e., age, disease, antibiotic, diet, environmental stressors etc.) influence the respiratory microbiome; whether the respiratory disease is a cause or effect of the changed microbiome in the respiratory system; whether the respiratory microbial biomarkers could accurately predict and diagnose the disease; how the microbe-microbe and host-microbe interactions are associated with health and disease; how the respiratory microbiome interacts with gut community and the whole body; and whether manipulation of the respiratory microbiome keep airway health and prevent disease occurrence or exacerbation. We propose that recently advanced technologies in the airway microbiome study could answer these urgent questions in full or partial.
This collection will show window from recent advancements in the field of respiratory microbiome in health and disease in either animals or humans. We welcome Original Research, Reviews, and Brief Research Report that focus on:
1. The respiratory microbiome structure: studies using sequencing technology to explore the airway microbial structure affected by factors such as age, disease, diet, antibiotics, climate, geography etc.
2. The microbiome multi-omics: studies utilizing multi-omics techniques (i.e., metagenomics, meta-transcriptomics, metabolomics, mycobiome, virome etc.) to enable a comprehensive understanding of the roles and biological mechanisms of the respiratory microbiome for disease, especially respiratory related diseases.
3. The roles of the respiratory microbiome: research investigating the roles of the airway microbiota in maintaining equilibrium of the respiratory ecosystem or in regulating host immunity/inflammation in disease, especially respiratory related diseases.
4. The gut-lung axis: studies investigating potential interactions between gut and lung microbiome and its role in health and respiratory diseases.
Respiratory diseases, such as COVID-19, pneumonia, asthma, chronic obstructive pulmonary disease, and lung cancer etc., are leading causes of death and disability in the world. With the development of sequencing technology, the critical roles of the respiratory microbiome in health and disease have been understood. As we know, a diverse and dynamic community of microbiome colonize on the inter-surface of the respiratory system. However, compared to gut ecosystem, less studies focus on the respiratory microbiome and its roles in health and disease. Although changed respiratory microbiome is associated with specific disease and host inflammation, more studies need to be conducted to broadly investigate the importance of the respiratory microbiome in health and disease.
As studies in the respiratory microbiome and its roles in health and disease continues to grow, several fundamental questions and challenges arise. They are: how the factors (i.e., age, disease, antibiotic, diet, environmental stressors etc.) influence the respiratory microbiome; whether the respiratory disease is a cause or effect of the changed microbiome in the respiratory system; whether the respiratory microbial biomarkers could accurately predict and diagnose the disease; how the microbe-microbe and host-microbe interactions are associated with health and disease; how the respiratory microbiome interacts with gut community and the whole body; and whether manipulation of the respiratory microbiome keep airway health and prevent disease occurrence or exacerbation. We propose that recently advanced technologies in the airway microbiome study could answer these urgent questions in full or partial.
This collection will show window from recent advancements in the field of respiratory microbiome in health and disease in either animals or humans. We welcome Original Research, Reviews, and Brief Research Report that focus on:
1. The respiratory microbiome structure: studies using sequencing technology to explore the airway microbial structure affected by factors such as age, disease, diet, antibiotics, climate, geography etc.
2. The microbiome multi-omics: studies utilizing multi-omics techniques (i.e., metagenomics, meta-transcriptomics, metabolomics, mycobiome, virome etc.) to enable a comprehensive understanding of the roles and biological mechanisms of the respiratory microbiome for disease, especially respiratory related diseases.
3. The roles of the respiratory microbiome: research investigating the roles of the airway microbiota in maintaining equilibrium of the respiratory ecosystem or in regulating host immunity/inflammation in disease, especially respiratory related diseases.
4. The gut-lung axis: studies investigating potential interactions between gut and lung microbiome and its role in health and respiratory diseases.