Biomechanotransduction is important cellular signaling in the extracellular matrix (ECM) and microenvironment. During development, embryonic stem cells (ESCs) undergo spatial compression, which precisely directs the lineage differentiation of the three layers. In adult tissues and organs, the interactions between cell-ECM and cell-fluid determine cellular morphology and function. In vitro, thanks to continuous advances in materials and engineering, specific biomechanotransduction in different cell types can be studied, such as specific surface structures, fluid shear stress, and cell deformation. The analysis of biomechanotransduction requires significant knowledge and advanced technology in the interdisciplinary fields of biology, materials, and engineering. By understanding biomechanotransduction, scientists can guide engineers to produce better biomaterials and medical devices as well as high-quality cells, providing more effective solutions for tissue repair and disease treatment.
This research topic aims to collect state-of-the-art studies and up-to-date reviews in the field of biomechanotransduction. Mammalian cells are regulated by complex physical and biochemical signals in their microenvironment. In recent years, biophysical effects such as the physicochemical property of extracellular matrix (ECM), shear stress of blood flow, and cell squeezing/stretching during cell migration have received increasing attention in transcriptome level, epigenetic state, and overall cell fate. The studies collected in this research topic provide the theoretical basis for the biophysical effects in cell biology, which can be applied to stem cells, regenerative medicine, biomaterials, and biomedical devices to produce high-quality cells and future biomaterials.
The scope of the research topic includes, but is not limited to:
1. Material surfaces and ECM (e.g. topography, patterns, stiffness, wettability).
2. Microfluidic devices (e.g. squeeze, shear stress).
3. Cell deformation (e.g. compression, stretching).
4. Other physical stimulation (e.g. electrical, light, heat).
5. New approaches to generate or characterize biomechanotransduction.
6. New devices, surfaces, or materials (e.g. dynamic surfaces or structures).
The types of manuscripts can be but are not limited to, original research, methods, review, and commentaries.
Biomechanotransduction is important cellular signaling in the extracellular matrix (ECM) and microenvironment. During development, embryonic stem cells (ESCs) undergo spatial compression, which precisely directs the lineage differentiation of the three layers. In adult tissues and organs, the interactions between cell-ECM and cell-fluid determine cellular morphology and function. In vitro, thanks to continuous advances in materials and engineering, specific biomechanotransduction in different cell types can be studied, such as specific surface structures, fluid shear stress, and cell deformation. The analysis of biomechanotransduction requires significant knowledge and advanced technology in the interdisciplinary fields of biology, materials, and engineering. By understanding biomechanotransduction, scientists can guide engineers to produce better biomaterials and medical devices as well as high-quality cells, providing more effective solutions for tissue repair and disease treatment.
This research topic aims to collect state-of-the-art studies and up-to-date reviews in the field of biomechanotransduction. Mammalian cells are regulated by complex physical and biochemical signals in their microenvironment. In recent years, biophysical effects such as the physicochemical property of extracellular matrix (ECM), shear stress of blood flow, and cell squeezing/stretching during cell migration have received increasing attention in transcriptome level, epigenetic state, and overall cell fate. The studies collected in this research topic provide the theoretical basis for the biophysical effects in cell biology, which can be applied to stem cells, regenerative medicine, biomaterials, and biomedical devices to produce high-quality cells and future biomaterials.
The scope of the research topic includes, but is not limited to:
1. Material surfaces and ECM (e.g. topography, patterns, stiffness, wettability).
2. Microfluidic devices (e.g. squeeze, shear stress).
3. Cell deformation (e.g. compression, stretching).
4. Other physical stimulation (e.g. electrical, light, heat).
5. New approaches to generate or characterize biomechanotransduction.
6. New devices, surfaces, or materials (e.g. dynamic surfaces or structures).
The types of manuscripts can be but are not limited to, original research, methods, review, and commentaries.