Disturbances of sleep and substance use are intertwined, where each one exacerbates the other via shared neurobiological mechanisms, contributing to increased initiation and maintenance of substance use and poor treatment outcomes. Sleep disturbances, being explicitly present in the substance use disorder clinical picture at all its stages, including use, withdrawal from use, remission, relapse, nevertheless get little attention as to its treatment. Insomnia is known to drive drug craving, contributing to relapse. Recognising and treating disrupted sleep could be an important preventive measure against further drug use and relapse. Sleep improvement, on the other hand, could influence better social functioning, mood improvement and cognitive productivity.
The overarching goal of this Research Topic is to present a collection of articles that help unite somewhat disparate areas of science on sleep and addiction in order to advance precision therapeutics approach for the treatment of substance use disorders. Sleep is a phenomenon that intertwines with core neurofunctional domains that are affected by addiction: cognitive control, emotionality, and incentive salience. A better understanding of the mechanism of sleep and its disruption can come via elucidation of its mediator or moderator role in addiction. We think it could be combined with the focus on its treatment and may help to discover new mechanistic approaches to treatment via multiple modalities, including behavioral treatments, devices, new medications, repurposed medications. A better understanding of the sources of variation in various sleep-related phenotypes in addiction may also contribute. We aim to spur the development of new pharmacotherapeutic, and therapeutic approaches to addiction treatment, with an emphasis on more recently discovered molecular targets, (e.g., the orexin system).
Topics could include, but are not limited to:
• The roles of sleep disturbance in substance use disorder treatment, including its association with treatment and recovery outcomes
• Underlying mechanisms of the intersection of sleep disturbance with addiction trajectories and recovery, such as components of neurofunction
• Patient reported data related to sleep, addiction, and recovery, including qualitative studies and patient reported outcomes
• Prevalence and biopsychosocial correlates of sleep disorders among individuals with substance use disorders, as well as sex differences in these associations
• The overlapping intersections of socioecological factors, including structural racism and gender, with sleep disturbance and addiction
• Equity in sleep health and addiction, such as studies highlighting disparities in and opportunities to strengthen outcomes and treatment benefit
Disturbances of sleep and substance use are intertwined, where each one exacerbates the other via shared neurobiological mechanisms, contributing to increased initiation and maintenance of substance use and poor treatment outcomes. Sleep disturbances, being explicitly present in the substance use disorder clinical picture at all its stages, including use, withdrawal from use, remission, relapse, nevertheless get little attention as to its treatment. Insomnia is known to drive drug craving, contributing to relapse. Recognising and treating disrupted sleep could be an important preventive measure against further drug use and relapse. Sleep improvement, on the other hand, could influence better social functioning, mood improvement and cognitive productivity.
The overarching goal of this Research Topic is to present a collection of articles that help unite somewhat disparate areas of science on sleep and addiction in order to advance precision therapeutics approach for the treatment of substance use disorders. Sleep is a phenomenon that intertwines with core neurofunctional domains that are affected by addiction: cognitive control, emotionality, and incentive salience. A better understanding of the mechanism of sleep and its disruption can come via elucidation of its mediator or moderator role in addiction. We think it could be combined with the focus on its treatment and may help to discover new mechanistic approaches to treatment via multiple modalities, including behavioral treatments, devices, new medications, repurposed medications. A better understanding of the sources of variation in various sleep-related phenotypes in addiction may also contribute. We aim to spur the development of new pharmacotherapeutic, and therapeutic approaches to addiction treatment, with an emphasis on more recently discovered molecular targets, (e.g., the orexin system).
Topics could include, but are not limited to:
• The roles of sleep disturbance in substance use disorder treatment, including its association with treatment and recovery outcomes
• Underlying mechanisms of the intersection of sleep disturbance with addiction trajectories and recovery, such as components of neurofunction
• Patient reported data related to sleep, addiction, and recovery, including qualitative studies and patient reported outcomes
• Prevalence and biopsychosocial correlates of sleep disorders among individuals with substance use disorders, as well as sex differences in these associations
• The overlapping intersections of socioecological factors, including structural racism and gender, with sleep disturbance and addiction
• Equity in sleep health and addiction, such as studies highlighting disparities in and opportunities to strengthen outcomes and treatment benefit
