Craniofacial deformity is a common disease caused by a variety of factors such as developmental disorders, trauma, tumors and multiple rare syndromes. Craniofacial deformity exhibited multi-systemic dysfunctions (e.g., bone, tooth, eye, ear and palate), which are harmful to the health and beauty of patients. The primary treatment for craniofacial deformity is stem cell tissue regeneration, which is the reproduction of development, so understanding the craniofacial development process is necessary for craniofacial regeneration. Though genomics studies have identified stem cells that dominate craniofacial development and regeneration, as well as mutants of craniofacial deformity, the specific cell lineage and underlying mechanisms, require further investigation. Targeted regulation of stem cell activity and stem cell injection are two classic strategies for craniofacial deformity treatment, but a full understanding of functional regeneration still remains elusive. As a result, focusing on stem cell-related mechanisms in craniofacial development and deformity regeneration is beneficial for craniofacial deformity treatment.
What is the role of stem cells in craniofacial development? What is the homogeneity and heterogeneity during development and regeneration, and how are stem cells activated and function? How can we improve current stem cell-based therapy for craniofacial deformity and defect regeneration? These are important questions in craniofacial science, and more research is needed to answer them. Furthermore, the identification of specific stem cells acting in specific craniofacial tissues, as well as lineage tracing, is required to determine their function. The cellular, genetic, and epigenetic maps of craniofacial development in humans and mice are both fundamental issues that deserve further investigation. The optimization of stem cell-targeted treatments in craniofacial regeneration, both in vivo and in vitro, should also be considered.
In this Research Topic, we encourage submissions of Original Research articles, Methods, Reviews, Mini Reviews and Perspectives on the following subtopics, including but not limited to:
• The role of stem cells in craniofacial development;
• The role of stem cells in craniofacial regeneration;
• Identification of specific stem cells/lineages in different craniofacial locations during development;
• Craniofacial tissue regeneration;
• The function of craniofacial stem cells.
Craniofacial deformity is a common disease caused by a variety of factors such as developmental disorders, trauma, tumors and multiple rare syndromes. Craniofacial deformity exhibited multi-systemic dysfunctions (e.g., bone, tooth, eye, ear and palate), which are harmful to the health and beauty of patients. The primary treatment for craniofacial deformity is stem cell tissue regeneration, which is the reproduction of development, so understanding the craniofacial development process is necessary for craniofacial regeneration. Though genomics studies have identified stem cells that dominate craniofacial development and regeneration, as well as mutants of craniofacial deformity, the specific cell lineage and underlying mechanisms, require further investigation. Targeted regulation of stem cell activity and stem cell injection are two classic strategies for craniofacial deformity treatment, but a full understanding of functional regeneration still remains elusive. As a result, focusing on stem cell-related mechanisms in craniofacial development and deformity regeneration is beneficial for craniofacial deformity treatment.
What is the role of stem cells in craniofacial development? What is the homogeneity and heterogeneity during development and regeneration, and how are stem cells activated and function? How can we improve current stem cell-based therapy for craniofacial deformity and defect regeneration? These are important questions in craniofacial science, and more research is needed to answer them. Furthermore, the identification of specific stem cells acting in specific craniofacial tissues, as well as lineage tracing, is required to determine their function. The cellular, genetic, and epigenetic maps of craniofacial development in humans and mice are both fundamental issues that deserve further investigation. The optimization of stem cell-targeted treatments in craniofacial regeneration, both in vivo and in vitro, should also be considered.
In this Research Topic, we encourage submissions of Original Research articles, Methods, Reviews, Mini Reviews and Perspectives on the following subtopics, including but not limited to:
• The role of stem cells in craniofacial development;
• The role of stem cells in craniofacial regeneration;
• Identification of specific stem cells/lineages in different craniofacial locations during development;
• Craniofacial tissue regeneration;
• The function of craniofacial stem cells.