Recent research advances have enhanced our comprehension of the basic pathogenesis of the most common inflammatory diseases such as chronic wounds, sepsis, and COVID-19, which bring about the development of some innovative approaches. Stem cell transplantation may provide an efficient therapy because of their self-renewal and differentiation capacity. However, safety concerns have limited the clinical application of this technique. It is indispensable to promoting the development of safe and efficient therapeutic strategies based on stem cells.
Recently, the performance of stem cells after transplantation has increasingly been attributed to their exocrine function-producing derivatives such as extracellular vesicles (EVs), cytokines, and cell-conditioned medium. EVs contain diverse cellular molecules including RNAs, DNAs, and proteins, promoting the information exchange between cells. Compared with their parental stem cells, EVs have several advantages including high safety, absence of immune reactions, fewer ethical issues, and decreased potential for embolism formation and carcinogenicity. Recent research reported the pivotal role of stem cell-derived EVs in a wide spectrum of diseases such as cancer, cardiopathy, and dermatosis. But the study on the role of stem cell-derived EVs in inflammatory diseases is still in the infancy.
The aim of this Research Topic is to reveal the role of stem cell derivatives, especially EVs, in the pathogenesis of inflammatory diseases. This Research Topic will also promote the diagnostic, prognostic, and therapeutic strategies based on stem cell derivatives (EVs) for inflammatory diseases.
We welcome Original Research articles, Mini-Reviews, Reviews, Opinions, and Case Reports on the following topics, but are not limited to:
1. Mechanisms of EVs-mediated initiation and progression of inflammatory diseases;
2. Development of EVs as diagnostic or prognostic biomarkers in inflammatory diseases;
3. Application of EVs as therapeutic tools in inflammatory diseases.
Recent research advances have enhanced our comprehension of the basic pathogenesis of the most common inflammatory diseases such as chronic wounds, sepsis, and COVID-19, which bring about the development of some innovative approaches. Stem cell transplantation may provide an efficient therapy because of their self-renewal and differentiation capacity. However, safety concerns have limited the clinical application of this technique. It is indispensable to promoting the development of safe and efficient therapeutic strategies based on stem cells.
Recently, the performance of stem cells after transplantation has increasingly been attributed to their exocrine function-producing derivatives such as extracellular vesicles (EVs), cytokines, and cell-conditioned medium. EVs contain diverse cellular molecules including RNAs, DNAs, and proteins, promoting the information exchange between cells. Compared with their parental stem cells, EVs have several advantages including high safety, absence of immune reactions, fewer ethical issues, and decreased potential for embolism formation and carcinogenicity. Recent research reported the pivotal role of stem cell-derived EVs in a wide spectrum of diseases such as cancer, cardiopathy, and dermatosis. But the study on the role of stem cell-derived EVs in inflammatory diseases is still in the infancy.
The aim of this Research Topic is to reveal the role of stem cell derivatives, especially EVs, in the pathogenesis of inflammatory diseases. This Research Topic will also promote the diagnostic, prognostic, and therapeutic strategies based on stem cell derivatives (EVs) for inflammatory diseases.
We welcome Original Research articles, Mini-Reviews, Reviews, Opinions, and Case Reports on the following topics, but are not limited to:
1. Mechanisms of EVs-mediated initiation and progression of inflammatory diseases;
2. Development of EVs as diagnostic or prognostic biomarkers in inflammatory diseases;
3. Application of EVs as therapeutic tools in inflammatory diseases.
