Stroke is one of the leading causes of death and disability worldwide. Among them, ischemic stroke is attributed to an abrupt blockage of blood flow to brain, while hemorrhagic stroke is caused by bleeding into brain. The principal aim of stroke therapy is to decrease mortality and reduce persistent neurologic injury and long-term disability. It also targets to prevent complications and recurrence after stroke as well as minimize the brain function loss caused by the cerebral damage. Fortunately, many strokes could be prevented through healthy lifestyle changes and controlling stroke risk factors, such as cigarette or tobacco smoking, high blood pressure, diabetes, and heart disease. Carotid endarterectomy and stenting of the cervical and intracranial vessels may help reduce recurrent stroke in some cases. Advanced treatments and rehabilitation are helping many stroke patients return to society and their families.
Therapies for both ischemic and hemorrhagic stroke are still limited. For ischemic stroke, applications of pharmacological and mechanical thrombolysis are limited by the therapeutic time window and high risks of complications, such as hemorrhagic transformation. And no standard pharmacologic strategies are available for hemorrhagic stroke. Although many therapies have been shown to be effective in preclinical studies of stroke, such as stem cell therapy and exosomes, almost none of them passed clinical trials, and the reasons for most failures have not been well identified. There is a substantial need for developing therapeutic agents to improve the prognosis of stroke. Moreover, growing insights into pathophysiology and underlying molecular mechanisms of stroke will assist in the development of future neuroprotective strategies, leading to successful clinical trials and translational research.
This Research Topic welcomes submissions of Original Research (or Brief Research Report), Reviews (or Mini-Review), Methods, Case Reports, Meta-analysis for providing a deep understanding to develop effective treatment strategies for ischemic and hemorrhagic stroke in the near future, but not limited to the following themes:
- Physio pathological mechanisms of ischemic/hemorrhagic stroke.
- Research or reviews to investigate the current knowledge in the field of bioinformatics approaches in stroke or stroke treatment
- Innovative research in neuroprotection, including pharmaceutical and non-pharmaceutical strategies, and ischemic/ hemorrhagic pre-, per-, or post-conditioning.
- Systematic reviews and meta-analyses on the management of stroke and post-stroke patients.
- Surgical therapies for cerebrovascular diseases to prevent hemorrhagic stroke
Stroke is one of the leading causes of death and disability worldwide. Among them, ischemic stroke is attributed to an abrupt blockage of blood flow to brain, while hemorrhagic stroke is caused by bleeding into brain. The principal aim of stroke therapy is to decrease mortality and reduce persistent neurologic injury and long-term disability. It also targets to prevent complications and recurrence after stroke as well as minimize the brain function loss caused by the cerebral damage. Fortunately, many strokes could be prevented through healthy lifestyle changes and controlling stroke risk factors, such as cigarette or tobacco smoking, high blood pressure, diabetes, and heart disease. Carotid endarterectomy and stenting of the cervical and intracranial vessels may help reduce recurrent stroke in some cases. Advanced treatments and rehabilitation are helping many stroke patients return to society and their families.
Therapies for both ischemic and hemorrhagic stroke are still limited. For ischemic stroke, applications of pharmacological and mechanical thrombolysis are limited by the therapeutic time window and high risks of complications, such as hemorrhagic transformation. And no standard pharmacologic strategies are available for hemorrhagic stroke. Although many therapies have been shown to be effective in preclinical studies of stroke, such as stem cell therapy and exosomes, almost none of them passed clinical trials, and the reasons for most failures have not been well identified. There is a substantial need for developing therapeutic agents to improve the prognosis of stroke. Moreover, growing insights into pathophysiology and underlying molecular mechanisms of stroke will assist in the development of future neuroprotective strategies, leading to successful clinical trials and translational research.
This Research Topic welcomes submissions of Original Research (or Brief Research Report), Reviews (or Mini-Review), Methods, Case Reports, Meta-analysis for providing a deep understanding to develop effective treatment strategies for ischemic and hemorrhagic stroke in the near future, but not limited to the following themes:
- Physio pathological mechanisms of ischemic/hemorrhagic stroke.
- Research or reviews to investigate the current knowledge in the field of bioinformatics approaches in stroke or stroke treatment
- Innovative research in neuroprotection, including pharmaceutical and non-pharmaceutical strategies, and ischemic/ hemorrhagic pre-, per-, or post-conditioning.
- Systematic reviews and meta-analyses on the management of stroke and post-stroke patients.
- Surgical therapies for cerebrovascular diseases to prevent hemorrhagic stroke
