About this Research Topic
The objective of this research topic compilation is to understand the basic mechanisms and factors involved in the interplay of these three prominent innate immune processes – NETosis, complement activation and pattern recognition in inflammatory mechanisms and their role in the pathophysiology and therapeutic advancements in inflammatory disorders. The research in this context essentially addresses to the new investigations carried out on the above direction and their translational implications, the goal is to explore a new avenue in the management of inflammatory disorders.
We, therefore welcome the innovative research work focusing on the basic and clinical aspects of systemic inflammatory disorders targeting the immune mechanisms mediated by neutrophils, complement components and pattern recognition receptors. Present and future aspects unravelling the complex triangular linkage of these innate processes and the development of drugs targeting the triad, holds promise to deliver newer therapeutic facets in modulating inflammation in chronic infections, autoimmune diseases and cancer.
This Research Topic will include the manuscripts unravelling the basic understanding and translational implications of pattern recognition receptors, complement components and their crosstalk. Importantly, this Research Topic is focused on research inferring an association of components of this triad with the pathophysiology of inflammatory disorders and scope of novel therapeutic strategies targeting these mechanisms. This research topic welcomes the submission of Original Research and Review/Mini-review manuscripts focusing on, but not strictly limited to the following sub-topics:
1. Molecular mechanisms of NETosis, complement activation, pattern recognition, their cross talks, modulation, and their role in inflammatory disorders.
2. Factors involved in NETosis, complement activation, pattern recognition receptor, their cross talks , and their implications for inflammatory disorders
3. Therapeutic opportunities of NETosis, complement activation, and pattern recognition for based novel drug candidate discovery.
4. Interaction of these three innate immune processes with adaptive immune responses and in disease development.
5. Advanced understanding on the individual and intersecting regulatory and signalling mechanisms of NETosis, complement activation, and pattern recognition.
6. Impairment of NETosis, complement activation, pattern recognition, and their immunological and pathological outcome.
7. Transcriptomics, proteomics and genomics to unravel novel markers of the innate immune pathways of NETosis, complement activation, and pattern recognition.
8. Significance of the factors involved in NETosis, complement components, pattern recognition and their interplay in cancer.
Keywords: NETosis, inflammatory disorders, Complement activation, Pattern recognition, autoimmune diseases, infections, cancer, regulation, factors, molecular mechanism, modulation, adaptive immunity, cross talks
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.