Recent studies on Reactive oxygen species (ROS) have found that ROS can achieve therapeutic purposes by accelerating tumor cell death. Various drugs that increase ROS levels and cause oxidative stress in cells are widely used in clinical practice. However, there is still a lack of unified research on oxidative stress in tumor treatment. In particular, there is no quantitative study on whether different levels of ROS in the body play an anti-cancer or pro-cancer role. Therefore, the application of pro-oxidant or antioxidant drugs for tumor treatment still needs further research, and the specific mechanism of its anti-tumor effect also needs to be further explored. Natural products refer to the chemical constituents or their metabolites in animals, plants, and microorganisms. As an important source of drug discovery, they have the characteristics of rich sources and novel and diverse structures. Currently, there are many sources derived from natural products or their derivatives. Molecularly targeted anti-tumor drugs are used for tumor treatment or are in clinical trials. The molecularly targeted antitumor drugs derived from natural products, or their derivatives are summarized according to their target classification, and the molecular mechanism of action, research progress, and prospect of various drugs are summarized.
In this Research Topic, we welcome studies on promoting tumor cell apoptosis through ROS action mode and exerting tumor suppressor effect (such as Fas-FasL, mitochondrial pathway, etc.), as well as studies on cell death processes by regulating ROS levels (e.g., mediating by P53) and screening of antitumor drugs for ROS-targeted therapy. These may include but are not limited to the following:
1. Discovery of natural compounds that regulate tumor oxidative/antioxidative processes.
2. Molecular mechanism of natural molecular compounds affecting tumor growth by regulating ROS levels (up-regulate/down-regulate).
3. Development of pro- and anti-oxidative drugs for the prevention and treatment of different cancers based on the dual roles of ROS in cancer progression.
4. Studies on the key targets for tumor therapy by predicting and discovering ROS-related substrates.
Please note:
• Manuscripts testing/summarizing anti-cancer focused natural product research and pharmacological approaches derived from traditional medicine should be submitted through the Frontiers in Pharmacology pathway only.
• Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Recent studies on Reactive oxygen species (ROS) have found that ROS can achieve therapeutic purposes by accelerating tumor cell death. Various drugs that increase ROS levels and cause oxidative stress in cells are widely used in clinical practice. However, there is still a lack of unified research on oxidative stress in tumor treatment. In particular, there is no quantitative study on whether different levels of ROS in the body play an anti-cancer or pro-cancer role. Therefore, the application of pro-oxidant or antioxidant drugs for tumor treatment still needs further research, and the specific mechanism of its anti-tumor effect also needs to be further explored. Natural products refer to the chemical constituents or their metabolites in animals, plants, and microorganisms. As an important source of drug discovery, they have the characteristics of rich sources and novel and diverse structures. Currently, there are many sources derived from natural products or their derivatives. Molecularly targeted anti-tumor drugs are used for tumor treatment or are in clinical trials. The molecularly targeted antitumor drugs derived from natural products, or their derivatives are summarized according to their target classification, and the molecular mechanism of action, research progress, and prospect of various drugs are summarized.
In this Research Topic, we welcome studies on promoting tumor cell apoptosis through ROS action mode and exerting tumor suppressor effect (such as Fas-FasL, mitochondrial pathway, etc.), as well as studies on cell death processes by regulating ROS levels (e.g., mediating by P53) and screening of antitumor drugs for ROS-targeted therapy. These may include but are not limited to the following:
1. Discovery of natural compounds that regulate tumor oxidative/antioxidative processes.
2. Molecular mechanism of natural molecular compounds affecting tumor growth by regulating ROS levels (up-regulate/down-regulate).
3. Development of pro- and anti-oxidative drugs for the prevention and treatment of different cancers based on the dual roles of ROS in cancer progression.
4. Studies on the key targets for tumor therapy by predicting and discovering ROS-related substrates.
Please note:
• Manuscripts testing/summarizing anti-cancer focused natural product research and pharmacological approaches derived from traditional medicine should be submitted through the Frontiers in Pharmacology pathway only.
• Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
