Sphingolipids / PUFA and Respiratory Syndrome

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Hridayesh Prakash

Amity Centre for Translational Research

Downstate Health Sciences University

Cornell University

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Sphingolipids and PUFA are crucial bioactive molecules and involved in several fundamental and patho-physiological conditions like asthma, cystic fibrosis, respiratory tract infection and acute lung injuries. Among various intracellular kinases; Sphingosine kinase is crucial and central for Sphingolipids metabolism. SphK-1 is a well-known regulator of intracellular calcium homeostasis, cellular differentiation, innate immunity; apoptosis and cancer while the role of these lipids remains unclear. Sphingosine kinase-1 / has shown some therapeutic importance for controlling pulmonary infection with Mycobacteria. Therefore, the current topic is introduced to foster / welcome research activities across the globe targeting various sphingolipids and their derivatives for the effective management of pulmonary infection with pathogenic bacteria and discuss the therapeutic benefits of sphingolipid in controlling respiratory syndrome among various research groups/ labs for future collaboration.

Sphingolipids and PUFA are crucial bioactive molecules and involved in several fundamental and patho-physiological conditions like asthma, cystic fibrosis, respiratory tract infection and acute lung injuries. Among various intracellular kinases; Sphingosine kinase is crucial and central for Sphingolipids metabolism. SphK-1 is a well-known regulator of intracellular calcium homeostasis, cellular differentiation, innate immunity; apoptosis and cancer while the role of these lipids remains unclear. Sphingosine kinase-1 / has shown some therapeutic importance for controlling pulmonary infection with Mycobacteria. Therefore, the current topic is introduced to foster / welcome research activities across the globe targeting various sphingolipids and their derivatives for the effective management of pulmonary infection with pathogenic bacteria and discuss the therapeutic benefits of sphingolipid in controlling respiratory syndrome among various research groups/ labs for future collaboration.

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Hridayesh Prakash

Amity Centre for Translational Research

Downstate Health Sciences University

Cornell University

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Frontiers in Immunology

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