As an interwoven conception involving immunological function and metabolic characteristics, immunometabolism is attracting extensive research from various perspectives for nearly a decade. In the field of the interplay between inflammation and cancer, immunometabolic potential has been proved on a huge amount of bioactive ingredients derived from natural products. This potential was also explored in therapeutic strategy and drug discovery, endowed with rich clinical significance. Nowadays, natural products in the spotlight meet the healthy trend for modern human beings, and training immunity or reprogramming metabolism is also to be expected. Hence, our present topic aims to address the immunometabolic modulation of those natural products, including in the aspects of combating chronic inflammation, controlling pro-tumorigenic transformation of inflammation, improving cancer or therapy elicited inflammation, etc. All overview and original papers, no matter of theoretical or experimental papers, are welcome.
The goal of our research topic is to provide a forum to advance research on the contribution of natural products’ immunometabolic modulation in inflammation and cancer. It includes multi-dimensional interventions in the progression from inflammation to cancer by all sorts of systems-based approaches in attempt to achieve a beneficial impact on therapy strategy and drug discovery.
The present topic focusing on the immunometabolic modulation of natural products has the bullet points below, which are also the specific themes we would like contributors to address:
1) Controlling pro-tumorigenic transformation of inflammation, including improving immunosuppressive microenvironment and immune evasion via the regulations of immune cells (myeloid or Treg cell) and auxiliary cells, immune checkpoints, and metabolism.
2) The signaling pathways involved in inflammation, immunity, and cancer, such as toll-like receptor (TLR), MYC, AMPK/Nrf2, and PD-1/PD-L1 pathways.
3) Interfering with the inflammation-related factors in tumor microenvironment, such as cytokines, metabolic modifiers, and growth factors.
4) Combating chronic inflammation which facilitates cancer development and multidrug resistance in a manner of immunometabolic modulation by natural products.
5) Improving cancer or therapy elicited inflammation in a manner of immunometabolic modulation by natural products.
6) Some innovative approaches, such as single-cell, CRISPR, multi-omics, metabolic flux balance analysis, genome-scale metabolic models, bioinformatics, system biology, and computational modeling.
As an interwoven conception involving immunological function and metabolic characteristics, immunometabolism is attracting extensive research from various perspectives for nearly a decade. In the field of the interplay between inflammation and cancer, immunometabolic potential has been proved on a huge amount of bioactive ingredients derived from natural products. This potential was also explored in therapeutic strategy and drug discovery, endowed with rich clinical significance. Nowadays, natural products in the spotlight meet the healthy trend for modern human beings, and training immunity or reprogramming metabolism is also to be expected. Hence, our present topic aims to address the immunometabolic modulation of those natural products, including in the aspects of combating chronic inflammation, controlling pro-tumorigenic transformation of inflammation, improving cancer or therapy elicited inflammation, etc. All overview and original papers, no matter of theoretical or experimental papers, are welcome.
The goal of our research topic is to provide a forum to advance research on the contribution of natural products’ immunometabolic modulation in inflammation and cancer. It includes multi-dimensional interventions in the progression from inflammation to cancer by all sorts of systems-based approaches in attempt to achieve a beneficial impact on therapy strategy and drug discovery.
The present topic focusing on the immunometabolic modulation of natural products has the bullet points below, which are also the specific themes we would like contributors to address:
1) Controlling pro-tumorigenic transformation of inflammation, including improving immunosuppressive microenvironment and immune evasion via the regulations of immune cells (myeloid or Treg cell) and auxiliary cells, immune checkpoints, and metabolism.
2) The signaling pathways involved in inflammation, immunity, and cancer, such as toll-like receptor (TLR), MYC, AMPK/Nrf2, and PD-1/PD-L1 pathways.
3) Interfering with the inflammation-related factors in tumor microenvironment, such as cytokines, metabolic modifiers, and growth factors.
4) Combating chronic inflammation which facilitates cancer development and multidrug resistance in a manner of immunometabolic modulation by natural products.
5) Improving cancer or therapy elicited inflammation in a manner of immunometabolic modulation by natural products.
6) Some innovative approaches, such as single-cell, CRISPR, multi-omics, metabolic flux balance analysis, genome-scale metabolic models, bioinformatics, system biology, and computational modeling.
