Systemic Regulation of Organ Homeostasis and Implications of Hormones and Immunity, Volume II

Given the success of the first edition of Systemic Regulation of Organ Homeostasis and Implications of Hormones and Immunity and the continuing advances in the field, we are pleased to announce the Volume II.



Tissue specific micromilieu has fundamental influence on the physiological functions of cells. The cells have the capacity to differentiate and organize into specialized tissues and organs. Any imbalance in the endocrine/cellular/ligand signaling results in local/systemic malfunctioning of the tissues leading to the diseases. This normally involves more than one system/signaling pathway. Although several studies have furnished sufficient information on various signaling pathways involved in the classical functions of every organ/tissue system, both autonomous and/or non-autonomous signaling are inter-linked with each other and our knowledge on the potential underlying mechanisms of interaction of two physiological systems like hormones and immunity remains elusive.

Hence, it is essential to understand these two systems in normal and pathological settings, which is important for understanding the disease biology and to identify potential interventions for the management of various metabolic/endocrine disorders, including cancer.



This Research Topic is aimed to discuss and unravel the idiopathic interactions of hormones and soluble mediators of immunity with emphasis on general organ development/function in normal and disease conditions. The main focus of this research topic is to understand the cross talk(s) between endocrine systems (hormones and signaling pathways) with innate and adaptive immunity.



In this Research Topic, we welcome the submission of Original Research and Reviews, Opinion articles, and evidence-based Perspective articles that include, but are not limited to the following sub-topics:

• Signaling and endocrine aspects of organ function in normal conditions and in specific disorders/diseases

• Classical and non-classical functions of sex steroids (estrogens and androgens)

• Positive and negative feedback system of the HPG and HPA axis

• Steroids, GH and glucocorticoids in energy management and oxidative stress

• Steroids and other hormones/signaling pathways in bone physiology and immune protection, etc.

• Tissue microenvironment, transcriptional and epigenetic mechanisms that regulate cellular, tissue and organ homeostasis

• Non-classical functions of immune cells in regulating tissue and organ function (including tissue remodeling, wound healing, etc.)

• Hormonal regulation of immune homeostasis, self-tolerance-autoimmunity (3/4ths of patients are female)

• Systemic regulation and transport of hormones and immune cells

• Impact of hormonal dysregulation on cancer progression

• Essential role of hormones in sex differentiation and development of gonads during the prenatal period