Cell death is a fundamental physiological process that is crucial for maintaining homeostasis. The absence of the ability to kill themselves promotes normal cells to be neoplasia and eventually become malignant, which was recognized as one of the “Hallmarks of cancer”. The dysregulated of cell death-related genes remarkably observed in various tumors, resulting in excessive proliferation, metastasis, and resistance to chemotherapy,. Studies uncovered the multi-forms of programmed cell death, including apoptosis, pyroptosis, necroptosis, and ion-induced cell death. Recently studies elucidated ion-induced cell death: Ferroptosis is a cell death caused by toxic iron-catalyzed reactive oxygen species (ROS). And cuproptosis is a copper-triggered form of cell death, which was proved independent of other types of cell death. The various forms of cell death pathways have crucial roles in tumorigenensis with significant clinical implications.
Although the forms of cell death have been constantly consummated, the complete mechanism and interaction of each other remain to illustrate. The causes of disordered cell death in tumorigenesis is a critical topic to clarify, which can lead us to protect high-risk populations from cancers by early screening and primary prevention.
Biomarkers of the early-stage disorder indicating the risks of cancers, which can be used in clinical application conveniently and noninvasive, are still unknown. The mechanism that cancer cells are resistant to CTL-induced killing cell death through immune checkpoints, tumor microenvironment, and others arouses tremendous interest. How to decrease the resistance to chemotherapy caused by the excessive process of anti-cell death and specifically target tumor cells to re-activate cell death killing themselves requires more research.
Potential topics include but are not limited to the following:
1) Novel molecular mechanism and clinical implication of tumor cell death including apoptosis, pyroptosis, necroptosis, ferroptosis, cuproptosis and others in cancers.
2) Cell death-related biomarkers in early identification of cancer risk factors.
3) The mechanism under cell death-induced resistance to chemotherapy, targeted therapy and immunotherapy.
4) The clinical trial studies attempting to apply cell death inhibitors to cancer treatment either alone or in combination
Cell death is a fundamental physiological process that is crucial for maintaining homeostasis. The absence of the ability to kill themselves promotes normal cells to be neoplasia and eventually become malignant, which was recognized as one of the “Hallmarks of cancer”. The dysregulated of cell death-related genes remarkably observed in various tumors, resulting in excessive proliferation, metastasis, and resistance to chemotherapy,. Studies uncovered the multi-forms of programmed cell death, including apoptosis, pyroptosis, necroptosis, and ion-induced cell death. Recently studies elucidated ion-induced cell death: Ferroptosis is a cell death caused by toxic iron-catalyzed reactive oxygen species (ROS). And cuproptosis is a copper-triggered form of cell death, which was proved independent of other types of cell death. The various forms of cell death pathways have crucial roles in tumorigenensis with significant clinical implications.
Although the forms of cell death have been constantly consummated, the complete mechanism and interaction of each other remain to illustrate. The causes of disordered cell death in tumorigenesis is a critical topic to clarify, which can lead us to protect high-risk populations from cancers by early screening and primary prevention.
Biomarkers of the early-stage disorder indicating the risks of cancers, which can be used in clinical application conveniently and noninvasive, are still unknown. The mechanism that cancer cells are resistant to CTL-induced killing cell death through immune checkpoints, tumor microenvironment, and others arouses tremendous interest. How to decrease the resistance to chemotherapy caused by the excessive process of anti-cell death and specifically target tumor cells to re-activate cell death killing themselves requires more research.
Potential topics include but are not limited to the following:
1) Novel molecular mechanism and clinical implication of tumor cell death including apoptosis, pyroptosis, necroptosis, ferroptosis, cuproptosis and others in cancers.
2) Cell death-related biomarkers in early identification of cancer risk factors.
3) The mechanism under cell death-induced resistance to chemotherapy, targeted therapy and immunotherapy.
4) The clinical trial studies attempting to apply cell death inhibitors to cancer treatment either alone or in combination