This Research Topic is the second volume of the “Community Series in the Role of Angiogenesis and Immune Response in Tumor Microenvironment of Solid Tumor". Please Volume I
here.
The microenvironment of tumors is consisted of the tumor stroma, proliferating tumor cells, infiltrating inflammatory cells, blood vessels, and various associated tissue cells. The pre-metastatic niche (PRN) is described as supportive and receptive, which undergoes cellular and molecular changes to form the fertile “soil” or metastatic-designated sites for metastatic tumor cell “seed” colonization. Thus, the PRN supports promoting tumor metastasis and tumor settlement in distant organs. The infiltration of the immune cells and the formation of blood vessels from the pre-metastatic sites are critical for the tumor microenvironment. Typically, the angiogenic factor is strongly associated with the inflammatory response during the development of tumors. Additionally, the immunoediting processes are essentially devoted to promoting angiogenesis and modulating the innate and specific immune responses.
In this research topic, we would like to share new findings and discussions on the role of angiogenesis and immune response in the tumor microenvironment of solid tumors. We welcome Review, Original Research, and Method articles in the following subtopics:
1) Novel mechanisms or targets connected with immune response and angiogenesis in solid tumors.
2) Tumor variation of angiogenesis and immune system.
3) Therapeutic advances impacting the immune system and angiogenesis in solid tumors.
4) Association of tumor-infiltrating immune cells on cancer.
5) Influence of anti-angiogenic normalization that advances the evolution of the immune system.
Please Note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this research topic.
This Research Topic is the second volume of the “Community Series in the Role of Angiogenesis and Immune Response in Tumor Microenvironment of Solid Tumor". Please Volume I
here.
The microenvironment of tumors is consisted of the tumor stroma, proliferating tumor cells, infiltrating inflammatory cells, blood vessels, and various associated tissue cells. The pre-metastatic niche (PRN) is described as supportive and receptive, which undergoes cellular and molecular changes to form the fertile “soil” or metastatic-designated sites for metastatic tumor cell “seed” colonization. Thus, the PRN supports promoting tumor metastasis and tumor settlement in distant organs. The infiltration of the immune cells and the formation of blood vessels from the pre-metastatic sites are critical for the tumor microenvironment. Typically, the angiogenic factor is strongly associated with the inflammatory response during the development of tumors. Additionally, the immunoediting processes are essentially devoted to promoting angiogenesis and modulating the innate and specific immune responses.
In this research topic, we would like to share new findings and discussions on the role of angiogenesis and immune response in the tumor microenvironment of solid tumors. We welcome Review, Original Research, and Method articles in the following subtopics:
1) Novel mechanisms or targets connected with immune response and angiogenesis in solid tumors.
2) Tumor variation of angiogenesis and immune system.
3) Therapeutic advances impacting the immune system and angiogenesis in solid tumors.
4) Association of tumor-infiltrating immune cells on cancer.
5) Influence of anti-angiogenic normalization that advances the evolution of the immune system.
Please Note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this research topic.
