Musculoskeletal disorders affect nearly 1.3 billion people worldwide. It is a great challenge for orthopaedic surgeons and scientists to develop advanced biomaterials and novel drugs for the effective treatment of various degenerative and inflammatory musculoskeletal disorders, e.g., osteoporosis, osteoporotic fracture, osteoarthritis, bone defects, etc. Thanks to advances in our understanding of the molecular biological mechanism of musculoskeletal disorders, a batch of drug candidates with therapeutic potential have been discovered and identified.
In addition, the newly developed orthopaedic biomaterials can be used as temporary implants to fix bone to other, permanent implant materials and, indeed, bioabsorbable implants; furthermore, they can also function as sophisticated scaffolds encapsulated with drug or stem cells for bone and cartilage regeneration. In addition, these biomaterials are also used in intelligent and targeted drug delivery to enhance its therapeutic effectiveness and avoid side effects. The rationale is to integrate novel orthopaedic biomaterials and newly developed drugs to optimize the treatment of musculoskeletal disorders.
Although great advances in orthopaedic biomaterials development and novel drug discovery have been made in past years, a lack of systematic review and integration of both parts, biomaterials development and drug discovery, remains. In addition, the underlying molecular mechanism of orthopaedic biomaterials and new drugs exerting beneficial effects must be well elaborated. Therefore, the main purpose of this Research Topic is to collect original research articles, reviews, and perspectives that summarize and integrate the current advances in novel biomaterials and drug development in orthopaedics and elaborate on their underlying mechanism.
The sub-themes of this Research Topic include but are not limited to the following:
• Novel orthopaedic biomaterials via sophisticated design and modification
• Scaffolds enriched with stem cells or drugs for bone and cartilage regeneration
• Intelligent and targeted drug delivery for treatment of musculoskeletal disorders
• The application of novel drugs in peri-operative treatment orthopaedic surgery
• Newly identified small molecules and peptides for improving bone regeneration, accelerating bone fracture healing, etc.
This Research Topic does not accept publication studies carried out with crude extracts or mixtures. Only the use of highly purified, chemically characterized compounds is acceptable.
Musculoskeletal disorders affect nearly 1.3 billion people worldwide. It is a great challenge for orthopaedic surgeons and scientists to develop advanced biomaterials and novel drugs for the effective treatment of various degenerative and inflammatory musculoskeletal disorders, e.g., osteoporosis, osteoporotic fracture, osteoarthritis, bone defects, etc. Thanks to advances in our understanding of the molecular biological mechanism of musculoskeletal disorders, a batch of drug candidates with therapeutic potential have been discovered and identified.
In addition, the newly developed orthopaedic biomaterials can be used as temporary implants to fix bone to other, permanent implant materials and, indeed, bioabsorbable implants; furthermore, they can also function as sophisticated scaffolds encapsulated with drug or stem cells for bone and cartilage regeneration. In addition, these biomaterials are also used in intelligent and targeted drug delivery to enhance its therapeutic effectiveness and avoid side effects. The rationale is to integrate novel orthopaedic biomaterials and newly developed drugs to optimize the treatment of musculoskeletal disorders.
Although great advances in orthopaedic biomaterials development and novel drug discovery have been made in past years, a lack of systematic review and integration of both parts, biomaterials development and drug discovery, remains. In addition, the underlying molecular mechanism of orthopaedic biomaterials and new drugs exerting beneficial effects must be well elaborated. Therefore, the main purpose of this Research Topic is to collect original research articles, reviews, and perspectives that summarize and integrate the current advances in novel biomaterials and drug development in orthopaedics and elaborate on their underlying mechanism.
The sub-themes of this Research Topic include but are not limited to the following:
• Novel orthopaedic biomaterials via sophisticated design and modification
• Scaffolds enriched with stem cells or drugs for bone and cartilage regeneration
• Intelligent and targeted drug delivery for treatment of musculoskeletal disorders
• The application of novel drugs in peri-operative treatment orthopaedic surgery
• Newly identified small molecules and peptides for improving bone regeneration, accelerating bone fracture healing, etc.
This Research Topic does not accept publication studies carried out with crude extracts or mixtures. Only the use of highly purified, chemically characterized compounds is acceptable.
