About this Research Topic

Background

The urinary system, as an active part of human body, is protected by immune system. The immune system is composed of two divisions of innate and adaptive immunity. By the leakage of strangers (or non-self molecules) into the system and passing through the ineffective innate immune responses, the second zone of immunity or adaptive immune system gets activated.

Interestingly, the immune system is constructed by different types of molecules, peptides, glycoproteins and cells which can be activated through a versatile of mechanisms and signaling pathways. In summary, the immune system is an interactive network between surface and circulating proteins and glycoproteins, receptors and circulating cells which can appeared or disappear in different situations. This feature can be seen in homeostasis, infectious diseases, autoimmune diseases and cancers. For example, Toll-like receptors, interleukins, etc. are pivotal biosensors which modulate the molecular mechanisms associated with innate immunity in the urinary system. Based on this knowledge, in theory each immune molecule can be recognized as an effective biomarker in diagnosis and treatment.

The urinary immune network consists of a huge number of cells, proteins, receptors, etc. which regulate, modulate and mediate different part of this interactive network. Moreover, the type of inducers determines the activation of specific signaling pathways and immune responses.
This Research Topic aims to include immune mechanisms, immune responses, immune activities, immune signaling pathways, immune biomolecules and in toto, immune network interactions, which are related to urinary system in any conditions of homeostasis, infectious diseases, autoimmune diseases, tumors and cancers in both males and females. Hence, studies into cellular and molecular aspects of immunity are encouraged in this Research Topic.

We welcome all manuscript types focusing on, but not limited to,

• Urinary immune system and urinary system microbiome in homeostatic conditions in all age ranges and genders
• Urinary immune system and various microbial uropathogens
• Urinary immune system and autoimmune diseases and associated factors
• Urinary immune system cancers
• Urinary Immune network interactions
• Urinary immune system biomarkers used for diagnostics and treatment

Keywords: Immune system, Urinary tract, Homeostasis, Diseases, Cancers

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