Neonatal hypoxic-ischemic encephalopathy (HIE) remains one of the most important causes of neurodevelopmental disorders in infants, even in developed countries. Over the last two decades, therapeutic hypothermia has been used successfully as a standard treatment for HIE. However, potential treatments used in addition to therapeutic hypothermia can contribute positively to the survival and future neurodevelopment of these infants.
For this Research Topic, we are particularly interested in clinical and experimental research on new cellular and molecular mechanisms related to HIE pathophysiology, and new treatments for HIE. We would also like to include studies on biomarkers to determine the severity of HIE. Therefore, we encourage the submission of original research, reports evaluating new methods, and articles examining different hypotheses and theories.
This Research Topic welcomes submissions including, but not limited to:
• Cell death and neuroprotection mechanisms in HIE;
• The role of immune cells and inflammatory mediators in the development of HIE and immunomodulatory therapies;
• Therapeutic effects of endogenous mechanisms of brain repair and regeneration;
• New therapeutic strategies for HIE, including cell therapies;
• Identification of diagnostic and prognostic biomarkers for HIE;
• Advanced imaging modalities to evaluate the function and structure of the brain and its response to treatments after HIE.
Neonatal hypoxic-ischemic encephalopathy (HIE) remains one of the most important causes of neurodevelopmental disorders in infants, even in developed countries. Over the last two decades, therapeutic hypothermia has been used successfully as a standard treatment for HIE. However, potential treatments used in addition to therapeutic hypothermia can contribute positively to the survival and future neurodevelopment of these infants.
For this Research Topic, we are particularly interested in clinical and experimental research on new cellular and molecular mechanisms related to HIE pathophysiology, and new treatments for HIE. We would also like to include studies on biomarkers to determine the severity of HIE. Therefore, we encourage the submission of original research, reports evaluating new methods, and articles examining different hypotheses and theories.
This Research Topic welcomes submissions including, but not limited to:
• Cell death and neuroprotection mechanisms in HIE;
• The role of immune cells and inflammatory mediators in the development of HIE and immunomodulatory therapies;
• Therapeutic effects of endogenous mechanisms of brain repair and regeneration;
• New therapeutic strategies for HIE, including cell therapies;
• Identification of diagnostic and prognostic biomarkers for HIE;
• Advanced imaging modalities to evaluate the function and structure of the brain and its response to treatments after HIE.