Multicomponent reactions (MCRs) is an approach that gathers all synthetic routes involving three or more starting materials in one synthetic operation to build bonds leading to remarkable complex scaffolds with excellent atom economy. This synthetic methodology is a sustainable approach where the compounds are efficiently elaborated in high yields, short time with economical use of energy. Commonly, the classification of MCRs reaction is a named reaction e.g. Biginelli, Strecker, Hantzsch, Ugi, Mannich, Passerini, Passerini-Dömling, Groebke-Blackburn-Bienaymé. To broaden molecules design, union of MCRs was recently developed by combining different types of MCRs in a one-pot reaction. Among those combinations include: combination of a Bredereck - Passerini-3CR, combination of Petasis-3CR and Ugi-4CR, combination of the Groebke-Bienaymé-Blackburn-3CR with Ugi-4CR and Passerini-3CR etc. This synthetic strategy allows elaborating efficiently and diversely complex scaffolds with multipurpose applications.
Multicomponent reactions have several applications. They are linked widely to medicinal chemistry towards drugs and clinical candidates elaboration, agrochemicals, synthesis of natural compounds, functional materials and macromolecules. The aim of this Research Topic is to highlight multicomponent reactions as a powerful and efficient synthetic methodology to develop functional scaffolds for versatile applications.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Multicomponent reactions
• Union of MCRs
• Sequential multicomponent reactions
• Diversity-oriented synthesis
• One-pot sequential cycloaddition reactions
• Catalytic sequential reactions
• Metal catalysed cascade reactions
• Microwave-assisted multicomponent reactions
• Solvent-free multicomponent reactions
Multicomponent reactions (MCRs) is an approach that gathers all synthetic routes involving three or more starting materials in one synthetic operation to build bonds leading to remarkable complex scaffolds with excellent atom economy. This synthetic methodology is a sustainable approach where the compounds are efficiently elaborated in high yields, short time with economical use of energy. Commonly, the classification of MCRs reaction is a named reaction e.g. Biginelli, Strecker, Hantzsch, Ugi, Mannich, Passerini, Passerini-Dömling, Groebke-Blackburn-Bienaymé. To broaden molecules design, union of MCRs was recently developed by combining different types of MCRs in a one-pot reaction. Among those combinations include: combination of a Bredereck - Passerini-3CR, combination of Petasis-3CR and Ugi-4CR, combination of the Groebke-Bienaymé-Blackburn-3CR with Ugi-4CR and Passerini-3CR etc. This synthetic strategy allows elaborating efficiently and diversely complex scaffolds with multipurpose applications.
Multicomponent reactions have several applications. They are linked widely to medicinal chemistry towards drugs and clinical candidates elaboration, agrochemicals, synthesis of natural compounds, functional materials and macromolecules. The aim of this Research Topic is to highlight multicomponent reactions as a powerful and efficient synthetic methodology to develop functional scaffolds for versatile applications.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Multicomponent reactions
• Union of MCRs
• Sequential multicomponent reactions
• Diversity-oriented synthesis
• One-pot sequential cycloaddition reactions
• Catalytic sequential reactions
• Metal catalysed cascade reactions
• Microwave-assisted multicomponent reactions
• Solvent-free multicomponent reactions