Experimental animals are valuable resources for studying the anatomy, development, and function of the retina. Animal studies have contributed to our knowledge of the pathogenesis of retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), inherited retinal degeneration (IRD), and glaucoma, as well as the testing of innovative treatments to restore normal vision. The majority of experimental studies, however, continue to rely primarily on end-point examinations with biochemically fixed retinas, leaving out a complete description of the natural dynamics of the complex biological interactions present in the intact eye and necessitating the sacrifice of a sizable number of animals at various time points in order to examine biological processes over time.
Noninvasive or minimally invasive in vivo study is required to advance our understanding of the underlying mechanisms of retinal biology. Modern imaging techniques promise to gather molecular, functional, and anatomical data while monitoring retinal tissues in real time in live animals. The non-destructive nature renders longitudinal studies with substantially reduced numbers of animals and allows precise monitoring of disease progression and response to therapy in animal models with different retinal diseases.
This Research Topic aims to disseminate various in vivo ophthalmic imaging techniques that could accelerate the development of novel therapies by allowing direct and repeatable visualization of the living retina. The collection of articles (original research articles and review articles) will highlight recent development and utilization of preclinical imaging techniques for the animal retina and could offer direction and advice to researchers who study vision impairment in animal models of retinal diseases and evaluate retinal structure and function following therapeutic intervention.
The list of possible topics comprises but is not limited to:
- Development of in vivo retinal imaging techniques for preclinical animal study.
- Utilization of in vivo imaging techniques, such as optical coherence tomography, scanning laser ophthalmoscopy, fundus photography, multiphoton imaging, photoacoustic tomography, laser speckle imaging, multispectral imaging, on animal models of retinal degenerative diseases.
Topic Editor, Taehoon Kim is employed by Genentech, Inc. All other Topic Editors declare no commercial or financial relationships that could be construed as a potential conflict of interest with regards to the Research Topic.
Experimental animals are valuable resources for studying the anatomy, development, and function of the retina. Animal studies have contributed to our knowledge of the pathogenesis of retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), inherited retinal degeneration (IRD), and glaucoma, as well as the testing of innovative treatments to restore normal vision. The majority of experimental studies, however, continue to rely primarily on end-point examinations with biochemically fixed retinas, leaving out a complete description of the natural dynamics of the complex biological interactions present in the intact eye and necessitating the sacrifice of a sizable number of animals at various time points in order to examine biological processes over time.
Noninvasive or minimally invasive in vivo study is required to advance our understanding of the underlying mechanisms of retinal biology. Modern imaging techniques promise to gather molecular, functional, and anatomical data while monitoring retinal tissues in real time in live animals. The non-destructive nature renders longitudinal studies with substantially reduced numbers of animals and allows precise monitoring of disease progression and response to therapy in animal models with different retinal diseases.
This Research Topic aims to disseminate various in vivo ophthalmic imaging techniques that could accelerate the development of novel therapies by allowing direct and repeatable visualization of the living retina. The collection of articles (original research articles and review articles) will highlight recent development and utilization of preclinical imaging techniques for the animal retina and could offer direction and advice to researchers who study vision impairment in animal models of retinal diseases and evaluate retinal structure and function following therapeutic intervention.
The list of possible topics comprises but is not limited to:
- Development of in vivo retinal imaging techniques for preclinical animal study.
- Utilization of in vivo imaging techniques, such as optical coherence tomography, scanning laser ophthalmoscopy, fundus photography, multiphoton imaging, photoacoustic tomography, laser speckle imaging, multispectral imaging, on animal models of retinal degenerative diseases.
Topic Editor, Taehoon Kim is employed by Genentech, Inc. All other Topic Editors declare no commercial or financial relationships that could be construed as a potential conflict of interest with regards to the Research Topic.
