Ferroptosis, an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, has been implicated in the development and therapeutic response of various tumor types. By regulating lipid metabolism, ferroptosis interact with tumor signaling pathways, which plays an important role in the crosstalk between immune cells and tumor cells in the tumor microenvironment. Ferroptosis functions as a tumor suppressor mechanism, and various tumor suppressors can sensitize cells to ferroptosis, such as tumor suppressor p53, which inhibits the expression of SLC7A11 to inhibit tumor growth. Given that emerging evidence has elucidated the roles of ferroptosis in the initiation, development, metastasis, and therapy resistance of cancer, a great deal of effort to develop anticancer therapies based on ferroptosis induction would be significant. The development of more effective and real-time ferroptosis detection methods will be helpful to identify patients susceptible to ferroptosis inducers. The identification of specific ferroptosis-related genes for biomarker discovery in tumor patients will be of great importance to develop more effective ferroptosis inducers. The combination of ferroptosis-inducing agents and chemotherapy, radiotherapy, targeted drugs and immunotherapy will be more effective in improving tumor treatment and overcoming resistance.
Although considerable progress has been made in the regulatory mechanisms of tumor ferroptosis, targeting ferroptosis for tumor vulnerability still faces enormous challenges. This research topic will deepen the understanding of ferroptosis induction and ferroptosis defense mechanisms, dissect the role and mechanism of ferroptosis in tumor suppression and tumor immunity, clarify the multiple vulnerabilities of cancer cells to ferroptosis, and explore ferroptosis-based therapeutic strategies.
In this research topic, we welcome researchers to submit perspectives, original articles, reviews, comments and letters on the following topics:
• Novel ferroptosis inducers and related mechanism
• Combination of ferroptosis-inducing agents and chemotherapy, radiotherapy, targeted drugs and immunotherapy.
• Target ferroptosis to overcome cancer therapy resistance
• Novel discoveries of cancer treatments based on organelles and specific Lipids in ferroptosis
• Ferroptosis biomarkers and new methods to detect ferroptosis
Other great insights into the molecular mechanism and cancer therapy strategies related to the interaction between ferroptosis and tumor signaling pathways/tumor immunity, and the crosstalk between epigenetics and ferroptosis are also welcome.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Ferroptosis, an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, has been implicated in the development and therapeutic response of various tumor types. By regulating lipid metabolism, ferroptosis interact with tumor signaling pathways, which plays an important role in the crosstalk between immune cells and tumor cells in the tumor microenvironment. Ferroptosis functions as a tumor suppressor mechanism, and various tumor suppressors can sensitize cells to ferroptosis, such as tumor suppressor p53, which inhibits the expression of SLC7A11 to inhibit tumor growth. Given that emerging evidence has elucidated the roles of ferroptosis in the initiation, development, metastasis, and therapy resistance of cancer, a great deal of effort to develop anticancer therapies based on ferroptosis induction would be significant. The development of more effective and real-time ferroptosis detection methods will be helpful to identify patients susceptible to ferroptosis inducers. The identification of specific ferroptosis-related genes for biomarker discovery in tumor patients will be of great importance to develop more effective ferroptosis inducers. The combination of ferroptosis-inducing agents and chemotherapy, radiotherapy, targeted drugs and immunotherapy will be more effective in improving tumor treatment and overcoming resistance.
Although considerable progress has been made in the regulatory mechanisms of tumor ferroptosis, targeting ferroptosis for tumor vulnerability still faces enormous challenges. This research topic will deepen the understanding of ferroptosis induction and ferroptosis defense mechanisms, dissect the role and mechanism of ferroptosis in tumor suppression and tumor immunity, clarify the multiple vulnerabilities of cancer cells to ferroptosis, and explore ferroptosis-based therapeutic strategies.
In this research topic, we welcome researchers to submit perspectives, original articles, reviews, comments and letters on the following topics:
• Novel ferroptosis inducers and related mechanism
• Combination of ferroptosis-inducing agents and chemotherapy, radiotherapy, targeted drugs and immunotherapy.
• Target ferroptosis to overcome cancer therapy resistance
• Novel discoveries of cancer treatments based on organelles and specific Lipids in ferroptosis
• Ferroptosis biomarkers and new methods to detect ferroptosis
Other great insights into the molecular mechanism and cancer therapy strategies related to the interaction between ferroptosis and tumor signaling pathways/tumor immunity, and the crosstalk between epigenetics and ferroptosis are also welcome.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
