Migraine is a common headache disorder that can be associated with high levels of disability. When migraine attacks increase in number and/or in intensity, preventive medications are needed along with the acute treatment of single attacks. The advent of new migraine-specific treatments in recent years has led to an expansion of the treatment possibilities of migraine and the possibility to treat an extended number of highly disabled individuals. However, there is a fraction of individuals with migraine that do not respond even to the most potent and specific preventive treatments. Those individuals fall into the category of resistant or refractory migraine. Individuals with those conditions are frequently encountered in primary care and in specialist headache centers; however, they are still poorly studied. Studying those individuals is important in clinical practice to identify individuals with unmet needs, eligible to innovative treatment approaches. Individuals with resistant or refractory migraine also constitute an interesting human model of migraine, as they resist to modulation of several neural pathways that are implied in the genesis of migraine. As such, individuals with resistant or refractory migraine are an interesting population to study still unknown neural pathways leading to migraine symptoms.
The aim of the present Research Topic is to collect high-quality research on resistant and refractory migraine. We aim at collecting papers from both basic and clinical science to stimulate the debate and highlight the innovations in the field. We also aim to promote research on novel treatment approaches, both pharmacological and non-pharmacological, and on novel treatment targets for migraine forms which poorly respond to preventive treatments.
We welcome any original articles of both basic and clinical sciences concerning the epidemiology, pathogenesis, and management of resistant and refractory migraine. The scope of the Topic will be to create a common reference for both basic and clinical scientists in the field.
Migraine is a common headache disorder that can be associated with high levels of disability. When migraine attacks increase in number and/or in intensity, preventive medications are needed along with the acute treatment of single attacks. The advent of new migraine-specific treatments in recent years has led to an expansion of the treatment possibilities of migraine and the possibility to treat an extended number of highly disabled individuals. However, there is a fraction of individuals with migraine that do not respond even to the most potent and specific preventive treatments. Those individuals fall into the category of resistant or refractory migraine. Individuals with those conditions are frequently encountered in primary care and in specialist headache centers; however, they are still poorly studied. Studying those individuals is important in clinical practice to identify individuals with unmet needs, eligible to innovative treatment approaches. Individuals with resistant or refractory migraine also constitute an interesting human model of migraine, as they resist to modulation of several neural pathways that are implied in the genesis of migraine. As such, individuals with resistant or refractory migraine are an interesting population to study still unknown neural pathways leading to migraine symptoms.
The aim of the present Research Topic is to collect high-quality research on resistant and refractory migraine. We aim at collecting papers from both basic and clinical science to stimulate the debate and highlight the innovations in the field. We also aim to promote research on novel treatment approaches, both pharmacological and non-pharmacological, and on novel treatment targets for migraine forms which poorly respond to preventive treatments.
We welcome any original articles of both basic and clinical sciences concerning the epidemiology, pathogenesis, and management of resistant and refractory migraine. The scope of the Topic will be to create a common reference for both basic and clinical scientists in the field.
