Overweight and obesity are associated with increased risk of 13 types of cancer. Both human and animal studies validated the link between obesity and cancer, highlighting the role of lifestyle factors in tumor prevention. Dietary patterns have been directly associated with increased or decreased cancer risk and epidemiological studies have highlighted the importance of physical activity and muscle function in cancer risk or prevention. Importantly, gender-specific differences related to genetic and lifestyle factors are known cancer risk factors and have been observed in tumor incidence, localization, and response to treatment as well as body fat storage/distribution and lifestyle. In addition, a better understanding of the regional differences in obesity prevalence and cancer risks might provide guidance on the most promising prevention and intervention strategies.
Increasing evidence link the occurrence of cancer in obese and overweight patients to long-lasting inflammation and higher than normal levels of insulin, insulin-like growth factor, and sex hormones. Given the rise of both obesity and cancer worldwide, is essential to understand the link between obesity and cancer etiology. Besides inflammation, physiological functions and pathological correlations of proteins intimately involved in the general metabolism of adipose tissue and the relevance of those compounds to cell proliferation or development could contribute to abnormal proliferation and migration leading to oncogenesis. Nevertheless, new biological pathways are still to be uncovered and could lead to new perspectives and targets for therapies.
This Research Topic will provide a comprehensive overview on the link between obesity and cancer risk. Topic Editors welcome the submission of Original Research, Review, Mini Review, and Perspective articles covering
- New signaling pathways linking obesity and cancer;
- New biomarkers in obesity-related cancer;
- Novel biotargets in obesity-related cancers
- Obesity and the efficacy of cancer therapies;
- Prospective interventions and treatments targeting the obesity-cancer link;
- Global epidemiology of obesity-related cancer onset and progression.
Overweight and obesity are associated with increased risk of 13 types of cancer. Both human and animal studies validated the link between obesity and cancer, highlighting the role of lifestyle factors in tumor prevention. Dietary patterns have been directly associated with increased or decreased cancer risk and epidemiological studies have highlighted the importance of physical activity and muscle function in cancer risk or prevention. Importantly, gender-specific differences related to genetic and lifestyle factors are known cancer risk factors and have been observed in tumor incidence, localization, and response to treatment as well as body fat storage/distribution and lifestyle. In addition, a better understanding of the regional differences in obesity prevalence and cancer risks might provide guidance on the most promising prevention and intervention strategies.
Increasing evidence link the occurrence of cancer in obese and overweight patients to long-lasting inflammation and higher than normal levels of insulin, insulin-like growth factor, and sex hormones. Given the rise of both obesity and cancer worldwide, is essential to understand the link between obesity and cancer etiology. Besides inflammation, physiological functions and pathological correlations of proteins intimately involved in the general metabolism of adipose tissue and the relevance of those compounds to cell proliferation or development could contribute to abnormal proliferation and migration leading to oncogenesis. Nevertheless, new biological pathways are still to be uncovered and could lead to new perspectives and targets for therapies.
This Research Topic will provide a comprehensive overview on the link between obesity and cancer risk. Topic Editors welcome the submission of Original Research, Review, Mini Review, and Perspective articles covering
- New signaling pathways linking obesity and cancer;
- New biomarkers in obesity-related cancer;
- Novel biotargets in obesity-related cancers
- Obesity and the efficacy of cancer therapies;
- Prospective interventions and treatments targeting the obesity-cancer link;
- Global epidemiology of obesity-related cancer onset and progression.
