According to WHO’s reports, the number of people aged 60 and older will double between 2020 to 2050 to reach 2.1 billion. Although every country in the world is experiencing population aging, low- and middle-income countries are facing even greater challenges, as two-thirds of the world’s older population is estimated to live in these areas. Various metabolic and degenerative health problems are associated with aging, including cardio-cerebrovascular diseases, diabetes, dementia, cancer, anemia, osteoarthritis, benign prostatic hyperplasia, and increased susceptibility to infection. How to promote healthy aging is a pressing global issue. In traditional medicine of many geographical regions, some natural herbs are long recognized as “anti-aging” medicines and showed clinical benefits in the prevention or treatment of aging and aging-associated diseases, such as Ginseng, Ganoderma lucidum, Rhodiola rosea, and so on. Previous shreds of evidence have suggested the involvement of processes such as oxidative stress, inflammation, mitochondrial function, and telomere homeostasis as potential therapeutic mechanisms of herbal medicines, yet more in-depth analysis of their pharmacological activity, as well as well-designed RCT trails, in metabolic and degenerative diseases of aging, are still in high demand.
The goal of this Research Topic is to create a platform for critically assessing the scientific and clinical pieces of evidence regarding the pharmaceutical application of herbal medicine in metabolic and degenerative diseases of aging. Manuscripts may cover in vitro models, animal models, and human studies. For laboratory studies involving pharmacological activities, those focusing on the identification of active components or compounds, or the synergistic effects among multiple active components, as well as the combinational usage of different model systems/novel techniques, are highly preferred. Herbal extracts or poly-herbal formulation studies are also accepted, but only when a detailed characterization of dominating chemical substances (using methods such as HPLC, LC-MS, GC-MS, etc.) is provided. The underlying molecular mechanisms of drug action are anticipated to be analyzed. For clinical studies, multi-center RCTs are preferred. Well-designed observational studies or meta-analyses will also be considered.
This Research Topic is seeking research on herbal medicine in metabolic and degenerative diseases of aging of traditional medicine in all geographical regions. Original research, reviews, and meta-analyses focusing on, but not limited to, the following subtopics are welcomed:
• Novel active substances of herbal medicine in the treatment of metabolic and degenerative diseases of aging
• Novel molecular mechanism or therapeutic targets of herbal medicine in the treatment of metabolic and degenerative diseases of aging
• Novel synergistic combinations of active substances in herbal medicine for treating metabolic and degenerative diseases of aging
• Novel techniques or model systems in the screening or mechanism discovery of herbal medicine for treating metabolic and degenerative diseases of aging
• Novel clinical applications or therapeutic strategies of herbal medicine in the treatment of metabolic and degenerative diseases of aging
All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here) and th eConPhyMP guidelines (https://doi.org/10.3389/fphar.2022.953205)
According to WHO’s reports, the number of people aged 60 and older will double between 2020 to 2050 to reach 2.1 billion. Although every country in the world is experiencing population aging, low- and middle-income countries are facing even greater challenges, as two-thirds of the world’s older population is estimated to live in these areas. Various metabolic and degenerative health problems are associated with aging, including cardio-cerebrovascular diseases, diabetes, dementia, cancer, anemia, osteoarthritis, benign prostatic hyperplasia, and increased susceptibility to infection. How to promote healthy aging is a pressing global issue. In traditional medicine of many geographical regions, some natural herbs are long recognized as “anti-aging” medicines and showed clinical benefits in the prevention or treatment of aging and aging-associated diseases, such as Ginseng, Ganoderma lucidum, Rhodiola rosea, and so on. Previous shreds of evidence have suggested the involvement of processes such as oxidative stress, inflammation, mitochondrial function, and telomere homeostasis as potential therapeutic mechanisms of herbal medicines, yet more in-depth analysis of their pharmacological activity, as well as well-designed RCT trails, in metabolic and degenerative diseases of aging, are still in high demand.
The goal of this Research Topic is to create a platform for critically assessing the scientific and clinical pieces of evidence regarding the pharmaceutical application of herbal medicine in metabolic and degenerative diseases of aging. Manuscripts may cover in vitro models, animal models, and human studies. For laboratory studies involving pharmacological activities, those focusing on the identification of active components or compounds, or the synergistic effects among multiple active components, as well as the combinational usage of different model systems/novel techniques, are highly preferred. Herbal extracts or poly-herbal formulation studies are also accepted, but only when a detailed characterization of dominating chemical substances (using methods such as HPLC, LC-MS, GC-MS, etc.) is provided. The underlying molecular mechanisms of drug action are anticipated to be analyzed. For clinical studies, multi-center RCTs are preferred. Well-designed observational studies or meta-analyses will also be considered.
This Research Topic is seeking research on herbal medicine in metabolic and degenerative diseases of aging of traditional medicine in all geographical regions. Original research, reviews, and meta-analyses focusing on, but not limited to, the following subtopics are welcomed:
• Novel active substances of herbal medicine in the treatment of metabolic and degenerative diseases of aging
• Novel molecular mechanism or therapeutic targets of herbal medicine in the treatment of metabolic and degenerative diseases of aging
• Novel synergistic combinations of active substances in herbal medicine for treating metabolic and degenerative diseases of aging
• Novel techniques or model systems in the screening or mechanism discovery of herbal medicine for treating metabolic and degenerative diseases of aging
• Novel clinical applications or therapeutic strategies of herbal medicine in the treatment of metabolic and degenerative diseases of aging
All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here) and th eConPhyMP guidelines (https://doi.org/10.3389/fphar.2022.953205)
