Molecular, cellular and model organism approaches for understanding the basis of neurological disease

99.1K

views

72

authors

14

articles

Molecular, cellular and model organism approaches for understanding the basis of neurological disease

99.1K

views

72

authors

14

articles

Editorial

20 March 2017

Editorial: Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease

Robert J. Harvey

and

Kirsten Harvey

2,345 views

2 citations

Editors

2

Robert J Harvey

University of the Sunshine Coast

University College London

Impact

About

The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. We encourage original research or methods papers, reviews, commentaries, or perspectives that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants.

The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. We encourage original research or methods papers, reviews, commentaries, or perspectives that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants.

Download ebook

Share

Editors

Robert J Harvey

University of the Sunshine Coast

University College London

Impact

99,126 Total views

68,809 Article views

27,691 Article downloads

2,626 Topic views

Published In

Journal Thumbnail

Frontiers in Molecular Neuroscience

Molecular Neuroscience Archive, Brain Disease Mechanisms, Molecular Signalling and Pathways, Methods and Model Organisms, Neuroplasticity and Development

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic