Gut-liver-brain axis: the complex interplay between Gut–Brain, Gut–Liver, and Liver–Brain axes, a multidirectional communication network, links the enteric, hepatic, and central nervous systems. This network has been extended to include endocrine, humoral, metabolic, and immune routes of communication. Through this network, the brain affects intestinal and hepatic activities, including the activity of innate immune cells and immune effector cells. Meanwhile, the gut and liver influence cognition and mental health through the regulation of microbiota and host immune responses.
Impaired gut-liver-brain axis in patients is associated with several diseases, such as hepatic encephalopathy, and Alzheimer's disease. The mechanisms behind these diseases are unclear although within-host evolution of gut microbiota, metabolism dysfunction, and systemic inflammation through gut dysbiosis have been proposed.
The research reveals new insights into the gut-liver-brain axis or discusses how the gut-liver-brain axis works in human health and diseases, such as neurodegenerative diseases and multiple types of cancer, are highly encouraged. While the Special Issue is associated with but not limited to the “Gut-liver-brain axis”, related works and progress are also encouraged. The research on the “Gut-liver-brain axis” involves biology, materials science, and chemistry. Such fields are challenging and with ample opportunities.
Gut-liver-brain axis: the complex interplay between Gut–Brain, Gut–Liver, and Liver–Brain axes, a multidirectional communication network, links the enteric, hepatic, and central nervous systems. This network has been extended to include endocrine, humoral, metabolic, and immune routes of communication. Through this network, the brain affects intestinal and hepatic activities, including the activity of innate immune cells and immune effector cells. Meanwhile, the gut and liver influence cognition and mental health through the regulation of microbiota and host immune responses.
Impaired gut-liver-brain axis in patients is associated with several diseases, such as hepatic encephalopathy, and Alzheimer's disease. The mechanisms behind these diseases are unclear although within-host evolution of gut microbiota, metabolism dysfunction, and systemic inflammation through gut dysbiosis have been proposed.
The research reveals new insights into the gut-liver-brain axis or discusses how the gut-liver-brain axis works in human health and diseases, such as neurodegenerative diseases and multiple types of cancer, are highly encouraged. While the Special Issue is associated with but not limited to the “Gut-liver-brain axis”, related works and progress are also encouraged. The research on the “Gut-liver-brain axis” involves biology, materials science, and chemistry. Such fields are challenging and with ample opportunities.
