Efficient Biomanufacturing via Microbial Cell Factories, volume II

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Jiangnan University

Washington University in St. Louis

University of Hawaii at Manoa

South China University of Technology

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This Research Topic is Volume II of a series. The previous volume, which has attracted over 34,000 views can be found here: Efficient Biomanufacturing via Microbial Cell Factories or Multi-Enzyme Molecular Machines.

Traditional chemical refining is based on non-renewable petroleum resources, having problems of high energy consumption and high pollution. By building efficient microbial cell factories, renewable biomass resources can be used as raw materials to produce various products. Particularly, with the advances in synthetic biology and genome editing in recent years, these new biological platforms can be created with diverse functions, achieving green and sustainable manufacturing to a large extent and thus greatly promote economic development.

The use of microbial cell factories for biomanufacturing needs to consider both technological and economic feasibility. To satisfy industrial production metrics TRY (i.e., titer, rate, and yield), it is necessary to consider:

- Designing the synthetic pathways;
- Analyzing and optimizing the multi-enzyme regulations;
- Characterizing of cell physiological performance and metabolic responses;
- Modeling metabolic process, enzyme reaction network, and genetic regulations.
- Using advanced synthetic biology tools such as high throughput genome editing, biosensor and artificial metabolon

Here, systems biology, evolution engineering and synthetic biology have to be integrated to construct new microbial cell factories with a high chance of industrial success.

The purpose of this Research Topic is to highlight the recent progress and trends in the development of efficient biomanufacturing via microbial cell factories. Manuscript submissions in the related areas are welcome. Potential topics include, but are not limited to:

- Microbial cell factory
- Computer-aided strain development
- Systems metabolic engineering
- Genome editing
- Modeling metabolic process
- Dynamic regulation strategies
- Biosensors and artificial metabolon in cell factory

This Research Topic is Volume II of a series. The previous volume, which has attracted over 34,000 views can be found here: Efficient Biomanufacturing via Microbial Cell Factories or Multi-Enzyme Molecular Machines.

Traditional chemical refining is based on non-renewable petroleum resources, having problems of high energy consumption and high pollution. By building efficient microbial cell factories, renewable biomass resources can be used as raw materials to produce various products. Particularly, with the advances in synthetic biology and genome editing in recent years, these new biological platforms can be created with diverse functions, achieving green and sustainable manufacturing to a large extent and thus greatly promote economic development.

The use of microbial cell factories for biomanufacturing needs to consider both technological and economic feasibility. To satisfy industrial production metrics TRY (i.e., titer, rate, and yield), it is necessary to consider:

- Designing the synthetic pathways;
- Analyzing and optimizing the multi-enzyme regulations;
- Characterizing of cell physiological performance and metabolic responses;
- Modeling metabolic process, enzyme reaction network, and genetic regulations.
- Using advanced synthetic biology tools such as high throughput genome editing, biosensor and artificial metabolon

Here, systems biology, evolution engineering and synthetic biology have to be integrated to construct new microbial cell factories with a high chance of industrial success.

The purpose of this Research Topic is to highlight the recent progress and trends in the development of efficient biomanufacturing via microbial cell factories. Manuscript submissions in the related areas are welcome. Potential topics include, but are not limited to:

- Microbial cell factory
- Computer-aided strain development
- Systems metabolic engineering
- Genome editing
- Modeling metabolic process
- Dynamic regulation strategies
- Biosensors and artificial metabolon in cell factory

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Editors

Jiangnan University

Washington University in St. Louis

University of Hawaii at Manoa

South China University of Technology

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Frontiers in Bioengineering and Biotechnology

Synthetic Biology

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