Tumor organoids derived from patient tumor tissues have highly retained the characteristics of the original tumor, including genetic alteration, pathological characteristics, and functional response, which makes it an important tool for basic tumor research, personalized medicine, and research and development of anti-cancer drugs. Compared with cancer cell lines and mouse xerographic models, tumor organoids have the advantages of high clinical relevance, rich individual diversity, high modeling success rate, gene manipulation friendliness, and suitability for high-throughput screening of drugs and targets, which makes them possibly the most promising type of tumor disease model.
Epigenetics regulation plays a critical role in carcinogenesis and tumor progression, which makes epigenetics research an important field in tumor early diagnosis and drug resistance. It is of great significance to find the key mechanisms, targets, and biomarkers of epigenetic regulation of tumor carcinogenesis and development. The organoid model and epigenetics illustrate the biological process of tumor disease from the perspectives of the disease model, function detection, and cell fate regulation respectively. Through organoid model and epigenetic research, it is possible to understand tumors from a new vision and discover new targets and biomarkers.
We welcome submissions of original research and review articles covering preclinical in vitro and in vivo work, translational research, and clinical studies, with highlights including but not limited to the following:
• Establishment and validation of preclinical tumor-like organ models in individualized cancer therapy
• Reproducing tumor microenvironment in immunotherapy based on organoid co-culture technology
• Tumor Evolution and Drug Response in Patient-Derived Organoid Models
• Research into the epigenetic regulation of cancer progression and treatment through in vitro human tumor organoids
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Tumor organoids derived from patient tumor tissues have highly retained the characteristics of the original tumor, including genetic alteration, pathological characteristics, and functional response, which makes it an important tool for basic tumor research, personalized medicine, and research and development of anti-cancer drugs. Compared with cancer cell lines and mouse xerographic models, tumor organoids have the advantages of high clinical relevance, rich individual diversity, high modeling success rate, gene manipulation friendliness, and suitability for high-throughput screening of drugs and targets, which makes them possibly the most promising type of tumor disease model.
Epigenetics regulation plays a critical role in carcinogenesis and tumor progression, which makes epigenetics research an important field in tumor early diagnosis and drug resistance. It is of great significance to find the key mechanisms, targets, and biomarkers of epigenetic regulation of tumor carcinogenesis and development. The organoid model and epigenetics illustrate the biological process of tumor disease from the perspectives of the disease model, function detection, and cell fate regulation respectively. Through organoid model and epigenetic research, it is possible to understand tumors from a new vision and discover new targets and biomarkers.
We welcome submissions of original research and review articles covering preclinical in vitro and in vivo work, translational research, and clinical studies, with highlights including but not limited to the following:
• Establishment and validation of preclinical tumor-like organ models in individualized cancer therapy
• Reproducing tumor microenvironment in immunotherapy based on organoid co-culture technology
• Tumor Evolution and Drug Response in Patient-Derived Organoid Models
• Research into the epigenetic regulation of cancer progression and treatment through in vitro human tumor organoids
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.