Recently, immunotherapy has emerged as an important therapeutic method for various types of cancers. Meanwhile, a series of studies have shown that the effect of cancer immunotherapy can be modulated by diet and nutrition. The advances of quantitative metabolic flux analysis, as well as in vivo imaging techniques of tumor metabolism, have enabled the scientists to study the role of diet and nutrition in cancer immunotherapy more thoroughly. Diet and nutrition have been revealed to affect the effect of cancer immunotherapy via distinct mechanisms: 1. modulation of the T cell function directly; 2. reshape the tumor microenvironment; 3. reprogram the metabolism in cancer cells. Although many studies have successfully demonstrated that it is feasible to potentiate the effect of cancer immunotherapy through modulation of diet and nutrition in multiple animal models, and some studies even proved that this strategy is also applicable in human, the functions and mechanisms of specific diets and nutrient factors remain largely unknown.
The goal of this research topic is to provide a forum to advance research on the roles of diet and nutrition on cancer immunotherapy. In this topic, we would like to summarize the recent achievements in understanding the functions and mechanisms of diet and nutrition on cancer immunotherapy, as well as to present original findings to introduce novel notions into this research field.
Potential topics can include, but are not limited to:
1)The role of dietary carbohydrate, lipids and amino acids in cancer immunotherapy;
2)The role of fasting in cancer immunotherapy;
3)The interaction between T cells and tumor microenvironment that is reshaped by diet and nutrient;
4)The effect of metabolic reprogramming in tumor cells on cancer therapy that is induced by diet and nutrient;
5)Regulation of the effect of cancer immunotherapy through modulation of the functions of other immune cells besides T cells, such as tumor-associated macrophages;
6)Regulation of the effect of cancer immunotherapy through manipulation of the microbiota by diet and nutrient.
Recently, immunotherapy has emerged as an important therapeutic method for various types of cancers. Meanwhile, a series of studies have shown that the effect of cancer immunotherapy can be modulated by diet and nutrition. The advances of quantitative metabolic flux analysis, as well as in vivo imaging techniques of tumor metabolism, have enabled the scientists to study the role of diet and nutrition in cancer immunotherapy more thoroughly. Diet and nutrition have been revealed to affect the effect of cancer immunotherapy via distinct mechanisms: 1. modulation of the T cell function directly; 2. reshape the tumor microenvironment; 3. reprogram the metabolism in cancer cells. Although many studies have successfully demonstrated that it is feasible to potentiate the effect of cancer immunotherapy through modulation of diet and nutrition in multiple animal models, and some studies even proved that this strategy is also applicable in human, the functions and mechanisms of specific diets and nutrient factors remain largely unknown.
The goal of this research topic is to provide a forum to advance research on the roles of diet and nutrition on cancer immunotherapy. In this topic, we would like to summarize the recent achievements in understanding the functions and mechanisms of diet and nutrition on cancer immunotherapy, as well as to present original findings to introduce novel notions into this research field.
Potential topics can include, but are not limited to:
1)The role of dietary carbohydrate, lipids and amino acids in cancer immunotherapy;
2)The role of fasting in cancer immunotherapy;
3)The interaction between T cells and tumor microenvironment that is reshaped by diet and nutrient;
4)The effect of metabolic reprogramming in tumor cells on cancer therapy that is induced by diet and nutrient;
5)Regulation of the effect of cancer immunotherapy through modulation of the functions of other immune cells besides T cells, such as tumor-associated macrophages;
6)Regulation of the effect of cancer immunotherapy through manipulation of the microbiota by diet and nutrient.