Although circadian variation in nociception and pain perception has been well-documented, the mechanism(s) underlying this circadian variation remains largely unknown. A better understanding of the interaction between circadian rhythms and nociceptive and/or pain processes is imperative for implementing patient-centric therapeutic regimens, and to reveal potential new targets to treat and manage pain. This Research Topic aims to explore the impact of circadian rhythms on pain. We welcome all original research and review articles that focus on, but are not limited to, the following topics:
• Temporal differences in pain
• Pain and sleep
• Chronic pain, its modulation by biological rhythms, as well as any sexual dimorphism
• How neurons and glial cells impact and are affected by chronic pain in animal models and human illnesses
• The behavioral, genetic and circuit mechanisms linking circadian rhythms and pain
Although circadian variation in nociception and pain perception has been well-documented, the mechanism(s) underlying this circadian variation remains largely unknown. A better understanding of the interaction between circadian rhythms and nociceptive and/or pain processes is imperative for implementing patient-centric therapeutic regimens, and to reveal potential new targets to treat and manage pain. This Research Topic aims to explore the impact of circadian rhythms on pain. We welcome all original research and review articles that focus on, but are not limited to, the following topics:
• Temporal differences in pain
• Pain and sleep
• Chronic pain, its modulation by biological rhythms, as well as any sexual dimorphism
• How neurons and glial cells impact and are affected by chronic pain in animal models and human illnesses
• The behavioral, genetic and circuit mechanisms linking circadian rhythms and pain