The microflora appears to be a signaling hub that integrates environmental factors, such as food and antigen inhalation, with genetic and immune signals to influence the host's metabolism and immune response to stimulation. The innate immune compartment, serving as the frontline between host and microbiota, is closely associated with the local microorganisms. The microenvironment in the tissue or organ (particularly in the gut) is sophisticatedly shaped by the reciprocal interactions between microflora and the local innate immune system.
Innate immunity may orchestrate the maintenance of key features of host-microbe symbiosis. While dysbiosis potentially alters the local immune system and sabotages the build-up or maintenance of self-tolerance, for example, the dysbiosis of gut microbiota could lead to the alteration of the toll-like receptor (TLR) pathway or inflammasome, which might trigger the changes in the systemic immune system and result in an autoreactive immune reaction. On the other hand, change in microbiota might be a consequence of genetic predisposition and external factors (e.g. food antigen) exposure, or a direct outcome of immune system disorders.
In a genetically susceptible host, the imbalances in the axis of “microflora-innate immunity” under defined environmental situations seem to contribute a lot to the pathogenesis of a multitude of immune-mediated disorders. The innate immunity and the cross-talk with microflora play crucial roles in maintaining immune homeostasis and shaping subsequent directions of immune polarization in response to stimulation. Further deciphering of the roles of innate immunity and microflora could prompt a huge leap in the treatment of immune-related diseases, including atopic disease (AD), autoimmune disease (AID), metabolic disease, infectious disease, and even neoplastic disease.
This Research Topic aims to investigate the crosstalk between innate immune responses and microflora in immune-related diseases, evaluating the possible effects on the regulations of immune recognition and polarization and the development of immune-related disorders. A deeper understanding of these issues would allow us to seek or establish a more personalized and precise therapy for these patients, better targeting the mechanisms responsible for the pathology.
We welcome the submission of Original Research and Review articles covering, but not limited to, the following sub-topics:
• The role of the microflora in innate immune homeostasis and its implications for disease development.
• Molecular mechanisms of bacterial components, metabolites, and other mediators of microflora interacting with the host innate immune system during health and in immune-related diseases.
• Crosstalk between innate immune and microflora in the regulation of immune recognition, immune direction shaping, and transformative potential of chronic inflammation.
• Barrier dysfunction and impaired innate immune – microflora crosstalk during immune-related diseases.
The microflora appears to be a signaling hub that integrates environmental factors, such as food and antigen inhalation, with genetic and immune signals to influence the host's metabolism and immune response to stimulation. The innate immune compartment, serving as the frontline between host and microbiota, is closely associated with the local microorganisms. The microenvironment in the tissue or organ (particularly in the gut) is sophisticatedly shaped by the reciprocal interactions between microflora and the local innate immune system.
Innate immunity may orchestrate the maintenance of key features of host-microbe symbiosis. While dysbiosis potentially alters the local immune system and sabotages the build-up or maintenance of self-tolerance, for example, the dysbiosis of gut microbiota could lead to the alteration of the toll-like receptor (TLR) pathway or inflammasome, which might trigger the changes in the systemic immune system and result in an autoreactive immune reaction. On the other hand, change in microbiota might be a consequence of genetic predisposition and external factors (e.g. food antigen) exposure, or a direct outcome of immune system disorders.
In a genetically susceptible host, the imbalances in the axis of “microflora-innate immunity” under defined environmental situations seem to contribute a lot to the pathogenesis of a multitude of immune-mediated disorders. The innate immunity and the cross-talk with microflora play crucial roles in maintaining immune homeostasis and shaping subsequent directions of immune polarization in response to stimulation. Further deciphering of the roles of innate immunity and microflora could prompt a huge leap in the treatment of immune-related diseases, including atopic disease (AD), autoimmune disease (AID), metabolic disease, infectious disease, and even neoplastic disease.
This Research Topic aims to investigate the crosstalk between innate immune responses and microflora in immune-related diseases, evaluating the possible effects on the regulations of immune recognition and polarization and the development of immune-related disorders. A deeper understanding of these issues would allow us to seek or establish a more personalized and precise therapy for these patients, better targeting the mechanisms responsible for the pathology.
We welcome the submission of Original Research and Review articles covering, but not limited to, the following sub-topics:
• The role of the microflora in innate immune homeostasis and its implications for disease development.
• Molecular mechanisms of bacterial components, metabolites, and other mediators of microflora interacting with the host innate immune system during health and in immune-related diseases.
• Crosstalk between innate immune and microflora in the regulation of immune recognition, immune direction shaping, and transformative potential of chronic inflammation.
• Barrier dysfunction and impaired innate immune – microflora crosstalk during immune-related diseases.