With the development of today's society, the impact of emotions on health and disease, intensified competition, and increased psychological pressure have attracted increasing attention from all walks of life. Both depression and premenstrual dysphoric disorder (PMDD) are common types of affective disorders seen in clinical practice. These disorders exhibit high morbidity, and seriously threaten peoples’ lives and health.
The regulation of emotions by the brain is specific to brain regions and cells, and involves complex changes in neural circuits and neuroendocrine levels. At present, 30%-40% of patients with depression or PMDD are insensitive to drug treatment. Furthermore, after drugs enter the brain, they act indiscriminately on drug targets throughout the brain, which inevitably brings serious side effects. Therefore, further research into the neural circuits and neural endocrine mechanisms of depression and PMDD, and moving towards translational medicine and drug development, are keys to solving the above problems.
The purpose of this Research Topic is to improve our understanding of the pathogenesis of depression and PMDD. This information will provide possible clues and a basis for clinical treatments and drug development. We particularly encourage animal experiments based on clinical efficacy, and especially welcome work in complementary and alternative medicine. We also encourage studies verifying clinical efficacy or pathogenesis directly within a population or group of patients. Such studies will provide more direct first-hand evidence of the pathogenesis of depression and PMDD.
Concerning the types of manuscripts, with the exception of theoretical/opinion papers and narrative literature reviews, all types of papers involving animal experiments or clinical trials will be considered for acceptance. We especially welcome proposed new animal models or experimental paradigms, as well as improvements to existing models and paradigms, because such models and paradigms are essential to the development and progress of this field.
With the development of today's society, the impact of emotions on health and disease, intensified competition, and increased psychological pressure have attracted increasing attention from all walks of life. Both depression and premenstrual dysphoric disorder (PMDD) are common types of affective disorders seen in clinical practice. These disorders exhibit high morbidity, and seriously threaten peoples’ lives and health.
The regulation of emotions by the brain is specific to brain regions and cells, and involves complex changes in neural circuits and neuroendocrine levels. At present, 30%-40% of patients with depression or PMDD are insensitive to drug treatment. Furthermore, after drugs enter the brain, they act indiscriminately on drug targets throughout the brain, which inevitably brings serious side effects. Therefore, further research into the neural circuits and neural endocrine mechanisms of depression and PMDD, and moving towards translational medicine and drug development, are keys to solving the above problems.
The purpose of this Research Topic is to improve our understanding of the pathogenesis of depression and PMDD. This information will provide possible clues and a basis for clinical treatments and drug development. We particularly encourage animal experiments based on clinical efficacy, and especially welcome work in complementary and alternative medicine. We also encourage studies verifying clinical efficacy or pathogenesis directly within a population or group of patients. Such studies will provide more direct first-hand evidence of the pathogenesis of depression and PMDD.
Concerning the types of manuscripts, with the exception of theoretical/opinion papers and narrative literature reviews, all types of papers involving animal experiments or clinical trials will be considered for acceptance. We especially welcome proposed new animal models or experimental paradigms, as well as improvements to existing models and paradigms, because such models and paradigms are essential to the development and progress of this field.
