Inflammatory bowel disease (IBD) is a chronic relapsing nonspecific intestinal inflammatory disease, mainly including Crohn's disease (CD) and ulcerative colitis (UC). The global incidence of IBD is increasing year by year. Since there is no clear treatment, it is a serious threat to human health. Therefore, it is urgent to develop a long-term effective treatment. The etiology of IBD is complex, involving environmental, genetic, infectious, and immune factors. Currently, the intestinal damage in IBD is believed to be caused by gut microbial stimulation that triggers abnormal immune responses to gut commensal bacteria in genetically susceptible individuals. Since gut microbiota dysbiosis plays an important role in the pathogenesis of IBD, gut microbiota intervention may be effective in the treatment of IBD. In addition to necessary surgery, traditional drug treatment is not only limited in effectiveness but also has potential toxic & side effects. Ethnic medicine interventions based on phytotherapy are considered to be more compliant and milder methods of gut microbiota regulation and thus have gradually attracted attention.
Many plant/food-derived natural products have been reported to exhibit the potential to treat IBD or to modulate gut microbiota, such as polyphenols. Any substance entering the intestinal tract, will have complex interactions with the microbiome. In this case, there are two dimensions involved, how the gut microbiota reshapes the body's molecular events during the disease process, and how potential small molecules interact with the gut microbiota to affect the disease, which is a very complex process. However, many scientific issues have not been clearly addressed in the past. The focus of this research topic is on the effects of herbal medicines both with potential effects directly on the disease targets relevant for -IBD or on the intestinal flora and its composition.
Therefore, this research topic focuses on the following questions / themes:
• What biochemical and microbiological changes occur when herbal medicines and isolated natural products interact with the gut microbiota?
• How can such preparations improve IBD clinically and pharmacologically by modulating gut microbiota?
• Review articles on the potential of specific plants to improve IBD or on the importance of such plants, for example. in TCM, European phytotherapy or Indian medical traditions
• The pharmacological mechanism and new application of such preparation to treat IBD
Please note:
Reviews and original research on related topics are welcome. The use of highly purified, chemically characterized compounds is acceptable. Studies on extracts with well-defined chemical bases are also considered. Purely in silico studies on supposed mechanisms of supposed actions of crude extracts and/or mixtures are generally not accepted since they are pharmacologically too preliminary. Pharmacological studies related to new targets are particularly welcome. We also encourage the application of dietary therapies in IBD.
Inflammatory bowel disease (IBD) is a chronic relapsing nonspecific intestinal inflammatory disease, mainly including Crohn's disease (CD) and ulcerative colitis (UC). The global incidence of IBD is increasing year by year. Since there is no clear treatment, it is a serious threat to human health. Therefore, it is urgent to develop a long-term effective treatment. The etiology of IBD is complex, involving environmental, genetic, infectious, and immune factors. Currently, the intestinal damage in IBD is believed to be caused by gut microbial stimulation that triggers abnormal immune responses to gut commensal bacteria in genetically susceptible individuals. Since gut microbiota dysbiosis plays an important role in the pathogenesis of IBD, gut microbiota intervention may be effective in the treatment of IBD. In addition to necessary surgery, traditional drug treatment is not only limited in effectiveness but also has potential toxic & side effects. Ethnic medicine interventions based on phytotherapy are considered to be more compliant and milder methods of gut microbiota regulation and thus have gradually attracted attention.
Many plant/food-derived natural products have been reported to exhibit the potential to treat IBD or to modulate gut microbiota, such as polyphenols. Any substance entering the intestinal tract, will have complex interactions with the microbiome. In this case, there are two dimensions involved, how the gut microbiota reshapes the body's molecular events during the disease process, and how potential small molecules interact with the gut microbiota to affect the disease, which is a very complex process. However, many scientific issues have not been clearly addressed in the past. The focus of this research topic is on the effects of herbal medicines both with potential effects directly on the disease targets relevant for -IBD or on the intestinal flora and its composition.
Therefore, this research topic focuses on the following questions / themes:
• What biochemical and microbiological changes occur when herbal medicines and isolated natural products interact with the gut microbiota?
• How can such preparations improve IBD clinically and pharmacologically by modulating gut microbiota?
• Review articles on the potential of specific plants to improve IBD or on the importance of such plants, for example. in TCM, European phytotherapy or Indian medical traditions
• The pharmacological mechanism and new application of such preparation to treat IBD
Please note:
Reviews and original research on related topics are welcome. The use of highly purified, chemically characterized compounds is acceptable. Studies on extracts with well-defined chemical bases are also considered. Purely in silico studies on supposed mechanisms of supposed actions of crude extracts and/or mixtures are generally not accepted since they are pharmacologically too preliminary. Pharmacological studies related to new targets are particularly welcome. We also encourage the application of dietary therapies in IBD.