Skin diseases are among the most prevalent health issues worldwide and are associated with complex traits arising from the interaction of genetic and environmental factors. Over 3000 entities of skin diseases are identified in the literature, including incurable and recurrent diseases like psoriasis, atopic dermatitis, and chronic ulcers, high incidence diseases like infectious skin diseases, and significant mortality diseases like malignant melanoma. Traditional Medical practices (TM) remain important in most regions of the world, which use herbal medicine for the treatment of various symptoms and diseases and for health promotion. Importantly, shreds of evidence show that TM is extraordinarily effective and advantageous for the treatment of skin diseases, particularly chronic ulcers, psoriasis, atopic dermatitis, and skin tumors. innate and adaptive immune system responses are involved in regulating many of these skin diseases. However, the mechanisms of action remain largely unexplored. The mechanism of action is not always clear due to the multi-target and multi-component character of the TM. The adoption of systems biology methods, especially the rapid development of network analysis, and multi-omics technology, may help to explore the mechanism of action of TM in skin disease treatment if these are combined with mechanistic pharmacological studies.
This Research Topic will focus on the effect and mechanism of Traditional Medicine on skin disease treatment, skin homeostasis, and skin remodeling. In particular, we encourage the submission of manuscripts focusing on skin homeostasis and skin remodeling in animal models, investigating the mechanisms of TM preparations at cellular levels, and exploring the therapeutic effects of TM for skin disease treatment. Multi-omics, including metabolomics, transcriptomics, and proteomics is becoming more vital in solving the above challenges of multi-component and multi-target interactions characteristic of traditional medicine. Network analysis and bioinformatics are actively explored to investigate TM mechanisms in the treatment of skin diseases such as psoriasis, atopic dermatitis, chronic ulcers, and skin tumors, with a focus on immune modulation. These findings will help to identify new pathways and potential targets, allowing for a better understanding and application of TM in the treatment of skin diseases.
We welcome the submission of manuscripts including, but not limited to, the following topics. All studies should explore the underlying TM mechanisms with specific emphasis on potential pharmacological characterization aimed at immune targets. In general, the studies may include an investigation into:
• The potential role of TM in the treatment of different skin diseases, especially skin chronic inflammatory disorder and skin tumors.
• The combined use of network analysis, bioinformatics, and multi-omics in combination with mechanistic pharmacological studies in order to explore the mechanism of action of such preparations.
• The molecular biological mechanisms of TM regulate the immune system in treating skin diseases (in vitro and in vivo evaluations).
• The discovery of biologically active compounds and biomarkers for diseases.
Purely in silico analyses of extracts are not within the journal’s scope. In such in silico work, ubiquitous compounds are often identified as alleged ‘actives’. This, however, is in no way evidence-based and such manuscripts will not be considered. The composition and preparation of the material must be described in detail, including a full authentication of the material used, the inclusion of valid species names, and chemical characterization of the preparations used. All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).
Skin diseases are among the most prevalent health issues worldwide and are associated with complex traits arising from the interaction of genetic and environmental factors. Over 3000 entities of skin diseases are identified in the literature, including incurable and recurrent diseases like psoriasis, atopic dermatitis, and chronic ulcers, high incidence diseases like infectious skin diseases, and significant mortality diseases like malignant melanoma. Traditional Medical practices (TM) remain important in most regions of the world, which use herbal medicine for the treatment of various symptoms and diseases and for health promotion. Importantly, shreds of evidence show that TM is extraordinarily effective and advantageous for the treatment of skin diseases, particularly chronic ulcers, psoriasis, atopic dermatitis, and skin tumors. innate and adaptive immune system responses are involved in regulating many of these skin diseases. However, the mechanisms of action remain largely unexplored. The mechanism of action is not always clear due to the multi-target and multi-component character of the TM. The adoption of systems biology methods, especially the rapid development of network analysis, and multi-omics technology, may help to explore the mechanism of action of TM in skin disease treatment if these are combined with mechanistic pharmacological studies.
This Research Topic will focus on the effect and mechanism of Traditional Medicine on skin disease treatment, skin homeostasis, and skin remodeling. In particular, we encourage the submission of manuscripts focusing on skin homeostasis and skin remodeling in animal models, investigating the mechanisms of TM preparations at cellular levels, and exploring the therapeutic effects of TM for skin disease treatment. Multi-omics, including metabolomics, transcriptomics, and proteomics is becoming more vital in solving the above challenges of multi-component and multi-target interactions characteristic of traditional medicine. Network analysis and bioinformatics are actively explored to investigate TM mechanisms in the treatment of skin diseases such as psoriasis, atopic dermatitis, chronic ulcers, and skin tumors, with a focus on immune modulation. These findings will help to identify new pathways and potential targets, allowing for a better understanding and application of TM in the treatment of skin diseases.
We welcome the submission of manuscripts including, but not limited to, the following topics. All studies should explore the underlying TM mechanisms with specific emphasis on potential pharmacological characterization aimed at immune targets. In general, the studies may include an investigation into:
• The potential role of TM in the treatment of different skin diseases, especially skin chronic inflammatory disorder and skin tumors.
• The combined use of network analysis, bioinformatics, and multi-omics in combination with mechanistic pharmacological studies in order to explore the mechanism of action of such preparations.
• The molecular biological mechanisms of TM regulate the immune system in treating skin diseases (in vitro and in vivo evaluations).
• The discovery of biologically active compounds and biomarkers for diseases.
Purely in silico analyses of extracts are not within the journal’s scope. In such in silico work, ubiquitous compounds are often identified as alleged ‘actives’. This, however, is in no way evidence-based and such manuscripts will not be considered. The composition and preparation of the material must be described in detail, including a full authentication of the material used, the inclusion of valid species names, and chemical characterization of the preparations used. All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).
