Most cellular organisms depend on intercellular communication to maintain physiological functions. Each cell can receive, process, and deliver molecular information to maintain the homeostasis of tissues and organs. It is believed that the important part of intercellular communication is the particles released from cells, such as exosomes, extracellular vesicles, oncosomes and microvesicles. They are nano-sized membrane-enclosed vesicles containing proteins, nucleic acids and other substances that can modify the cell microenvironment. Changes in the contents of these vesicles or in their biogenesis will affect cellular communication and lead to pathological events.
It is now understood that the malignant properties and progression of tumors are not entirely controlled by tumor cells. Cancer is increasingly seen as an ecosystem in which tumor cells interact with other cells, known as the tumor microenvironment, so cell communication is particularly important. The tumor microenvironment is a complex network in which tumor cells not only communicate with each other, but also with stromal cells and immune cells, which plays an important role in supporting tumor phenotypes. Therefore, it is important to explore the molecular mechanisms of Intercellular communication in tumors for the development of cancer therapy.
In view of the crucial role of intercellular communication in the initiation and promotion of tumors, it is particularly important to explore the molecular mechanism of communication between tumor cells or between tumor cells and stromal cells, immune cells. Through this study, the specific regulatory mechanism, regulatory network and key molecular events of intercellular communication in tumor progression can be partially elucidated, providing new ideas for cancer treatment strategies targeting intercellular communication.
We welcome submissions on the following topics, but are not limited to:
- Role of intercellular communication in tumor
- Specific mechanism of intercellular communication
- Biogenesis and secretion of extracellular vesicles
- Role of extracellular vesicle contents in tumor
Guest Editor Baochuan Guo is the founder and CEO of GLC Biotechnology and declares no competing interests with regards to the Research Topic Subject.
Most cellular organisms depend on intercellular communication to maintain physiological functions. Each cell can receive, process, and deliver molecular information to maintain the homeostasis of tissues and organs. It is believed that the important part of intercellular communication is the particles released from cells, such as exosomes, extracellular vesicles, oncosomes and microvesicles. They are nano-sized membrane-enclosed vesicles containing proteins, nucleic acids and other substances that can modify the cell microenvironment. Changes in the contents of these vesicles or in their biogenesis will affect cellular communication and lead to pathological events.
It is now understood that the malignant properties and progression of tumors are not entirely controlled by tumor cells. Cancer is increasingly seen as an ecosystem in which tumor cells interact with other cells, known as the tumor microenvironment, so cell communication is particularly important. The tumor microenvironment is a complex network in which tumor cells not only communicate with each other, but also with stromal cells and immune cells, which plays an important role in supporting tumor phenotypes. Therefore, it is important to explore the molecular mechanisms of Intercellular communication in tumors for the development of cancer therapy.
In view of the crucial role of intercellular communication in the initiation and promotion of tumors, it is particularly important to explore the molecular mechanism of communication between tumor cells or between tumor cells and stromal cells, immune cells. Through this study, the specific regulatory mechanism, regulatory network and key molecular events of intercellular communication in tumor progression can be partially elucidated, providing new ideas for cancer treatment strategies targeting intercellular communication.
We welcome submissions on the following topics, but are not limited to:
- Role of intercellular communication in tumor
- Specific mechanism of intercellular communication
- Biogenesis and secretion of extracellular vesicles
- Role of extracellular vesicle contents in tumor
Guest Editor Baochuan Guo is the founder and CEO of GLC Biotechnology and declares no competing interests with regards to the Research Topic Subject.