Central nervous system (CNS) injury and disease are one of the major causes of disability and paralysis in patients worldwide. Neuro-immune interaction and balance are critical for defense and homeostasis. After CNS injury, this balance is disrupted. First, immune cells infiltrate into the injury site after injury, leading to further aggravation of CNS injury through inflammatory response. However, the role of immune cells and CNS damage in the immune system is far more complex than this. Immune cells can also remove dead cells and myelin sheath debris, and also secrete neurotrophic factors. Conversely, the nervous system regulates the behavior and function of immune cells through multiple pathways, such as the autonomic nervous system and adrenal signals. Thus, further studies are needed to elucidate the relationship and mechanism between the immune system and CNS injury.
In recent years, single-cell sequencing, spatial transcriptomics, molecular imaging, artificial intelligence, targeted drugs, and other technologies have developed rapidly. These techniques can elucidate the changes in cellular components, the cellular behavior and function of immune cells, the key molecular mechanisms that regulate immune cell processes, and the changes and repair of nerve cells under the influence of immune cells after CNS injury.
The aim of this Research Topic is to collect recent advances and novel breakthroughs on the roles of immune cells, inflammatory response, and oxidative stress in CNS injury. We collect Original Research and Review articles that cover, but are not limited to, the following subtopics:
1) Mechanisms of immune activation after CNS injury and disease.
2) Detail roles of immunocytes in the initial and development of CNS injury and disease.
3) Novel methods and techniques for detecting cell behaviors of immune cells and neurons after CNS injury.
4) Spatial transcriptome, single-cell sequencing, bioinformatics analysis on CNS injury.
5) Research and development of immunomodulatory drugs and mechanism exploration on CNS injury.
6) The interaction between immunocytes and neurons.
Central nervous system (CNS) injury and disease are one of the major causes of disability and paralysis in patients worldwide. Neuro-immune interaction and balance are critical for defense and homeostasis. After CNS injury, this balance is disrupted. First, immune cells infiltrate into the injury site after injury, leading to further aggravation of CNS injury through inflammatory response. However, the role of immune cells and CNS damage in the immune system is far more complex than this. Immune cells can also remove dead cells and myelin sheath debris, and also secrete neurotrophic factors. Conversely, the nervous system regulates the behavior and function of immune cells through multiple pathways, such as the autonomic nervous system and adrenal signals. Thus, further studies are needed to elucidate the relationship and mechanism between the immune system and CNS injury.
In recent years, single-cell sequencing, spatial transcriptomics, molecular imaging, artificial intelligence, targeted drugs, and other technologies have developed rapidly. These techniques can elucidate the changes in cellular components, the cellular behavior and function of immune cells, the key molecular mechanisms that regulate immune cell processes, and the changes and repair of nerve cells under the influence of immune cells after CNS injury.
The aim of this Research Topic is to collect recent advances and novel breakthroughs on the roles of immune cells, inflammatory response, and oxidative stress in CNS injury. We collect Original Research and Review articles that cover, but are not limited to, the following subtopics:
1) Mechanisms of immune activation after CNS injury and disease.
2) Detail roles of immunocytes in the initial and development of CNS injury and disease.
3) Novel methods and techniques for detecting cell behaviors of immune cells and neurons after CNS injury.
4) Spatial transcriptome, single-cell sequencing, bioinformatics analysis on CNS injury.
5) Research and development of immunomodulatory drugs and mechanism exploration on CNS injury.
6) The interaction between immunocytes and neurons.