Targeted cancer metabolic pathway anti-cancer drugs achieved great success in malignant cancer treatment, however, inevitably the effect of almost all these drugs is compromised by the development of resistance. Given that recent evidence shows cancer cell metabolic reprogramming occurs after drug treatment, probably, there is a strong relationship between a specific target and particular metabolic pathway remodeling. Understanding the hidden fact and mechanisms under cell metabolism modulated by specific drug targets (in particular those related to precision medicine) may lead to the development of new therapeutic strategies to overcome drug resistance.
In this research topic, a first goal is to get new insights on how cancer cell metabolism is modulated by drug targets? Next, we want to understand what are the critical metabolic pathway or metabolites that contribute to specific targeted-drug resistance? A final question then relates to the existence or development of metabolism-targeting drug that can overcome specific drug resistance?
This research topic will thus welcome studies that characterize the metabolic remodeling in a cancer cell or cancer tissue from patients after targeted-drug treatment, especially when resistance develops afterwards. Also, we are interested in manuscripts reporting promising metabolism-targeting drugs that may overcome targeted drug-resistance. In addition, development of new technologies and multi-omics approaches to address the above issues will be considered. Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will however not be accepted.
The following sub-topics are included in the Research Topic, but are not limited to:
• Cancer Metabolism and precision medicine
• Drug targets and metabolism-targeting drugs
• Multi-omics and further validation of “metabolic” drugs overcoming resistance
Targeted cancer metabolic pathway anti-cancer drugs achieved great success in malignant cancer treatment, however, inevitably the effect of almost all these drugs is compromised by the development of resistance. Given that recent evidence shows cancer cell metabolic reprogramming occurs after drug treatment, probably, there is a strong relationship between a specific target and particular metabolic pathway remodeling. Understanding the hidden fact and mechanisms under cell metabolism modulated by specific drug targets (in particular those related to precision medicine) may lead to the development of new therapeutic strategies to overcome drug resistance.
In this research topic, a first goal is to get new insights on how cancer cell metabolism is modulated by drug targets? Next, we want to understand what are the critical metabolic pathway or metabolites that contribute to specific targeted-drug resistance? A final question then relates to the existence or development of metabolism-targeting drug that can overcome specific drug resistance?
This research topic will thus welcome studies that characterize the metabolic remodeling in a cancer cell or cancer tissue from patients after targeted-drug treatment, especially when resistance develops afterwards. Also, we are interested in manuscripts reporting promising metabolism-targeting drugs that may overcome targeted drug-resistance. In addition, development of new technologies and multi-omics approaches to address the above issues will be considered. Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will however not be accepted.
The following sub-topics are included in the Research Topic, but are not limited to:
• Cancer Metabolism and precision medicine
• Drug targets and metabolism-targeting drugs
• Multi-omics and further validation of “metabolic” drugs overcoming resistance