The urogenital tract is the body's natural passageway in close contact with urine. Propelled by sequencing technologies such as 16S rRNA and culturomics such as Enhanced quantitative urine culture (EQUC), great advances have been made in understanding the pivotal contribution of the microbiota to human health and genitourinary diseases. The healthy urogenital tract has been confirmed to harbour diverse and abundant microbes, overturning the dogma that urine is sterile. The microbiota plays a critical role in development, progression in genitourinary disease, such as Kidney stones, bladder cancer and prostate cancer. Urinary microbiota, which similar to the gut microbiota influences genitourinary disease outcome by triggering the inflammatory response and altering the immune system to disrupt homeostatic immunity. Besides, dysbiosis of the intestinal microbiome appears to be involved in in genitourinary disease development and progression through the gut-kidney axis. The human microbiota has potential significant implications for the etiology of genitourinary diseases, which offered a novel perspective on diagnostic, therapeutic and prognostic strategies.
This Research Topic focuses on inspiring novel insights into the role of urinary microbiota and gut microbiota in the development and progression of genitourinary diseases, especially kidney stones and urologic malignancies. We welcome Original Research and Review articles on the following aspects (Submissions may focus on, but are not limited to following subtopics):
? Defining the urinary microbiota of Genitourinary Diseases through the latest microbiome sequencing.
? Effect of gut microbiota in the development and progression of kidney stones and urologic malignancies.
? The role of urinary microbiota mediated immunity and inflammation in genitourinary tumorigenesis and development and stone formation.
? Application of antibacterial biofilm materials in the treatment of Genitourinary Diseases.
? Effects of emerging urological microbiological therapy on complications of lithectomy.
The urogenital tract is the body's natural passageway in close contact with urine. Propelled by sequencing technologies such as 16S rRNA and culturomics such as Enhanced quantitative urine culture (EQUC), great advances have been made in understanding the pivotal contribution of the microbiota to human health and genitourinary diseases. The healthy urogenital tract has been confirmed to harbour diverse and abundant microbes, overturning the dogma that urine is sterile. The microbiota plays a critical role in development, progression in genitourinary disease, such as Kidney stones, bladder cancer and prostate cancer. Urinary microbiota, which similar to the gut microbiota influences genitourinary disease outcome by triggering the inflammatory response and altering the immune system to disrupt homeostatic immunity. Besides, dysbiosis of the intestinal microbiome appears to be involved in in genitourinary disease development and progression through the gut-kidney axis. The human microbiota has potential significant implications for the etiology of genitourinary diseases, which offered a novel perspective on diagnostic, therapeutic and prognostic strategies.
This Research Topic focuses on inspiring novel insights into the role of urinary microbiota and gut microbiota in the development and progression of genitourinary diseases, especially kidney stones and urologic malignancies. We welcome Original Research and Review articles on the following aspects (Submissions may focus on, but are not limited to following subtopics):
? Defining the urinary microbiota of Genitourinary Diseases through the latest microbiome sequencing.
? Effect of gut microbiota in the development and progression of kidney stones and urologic malignancies.
? The role of urinary microbiota mediated immunity and inflammation in genitourinary tumorigenesis and development and stone formation.
? Application of antibacterial biofilm materials in the treatment of Genitourinary Diseases.
? Effects of emerging urological microbiological therapy on complications of lithectomy.