The response to treatment might be quite diverse within patients bearing solid tumors, mainly due to genetic factors. In order to define the key determinants of such heterogeneity and to design personalized schedules of treatment for each patient, it is of pivotal importance to study how genetic profile influences response to therapy. This is termed pharmacogenetics (or pharmacogenomics). In the latest years, improvements in molecular technologies such as microarrays, genotyping and high throughput DNA sequencing gave impulse to the broader use of pharmacogenetics. These approaches will possibly lead to the development of personalized drugs to treat cancer as well as other pathological conditions (Alzheimer disease, asthma, cardiovascular diseases and many more).
This Research Topic aims to update the currently available information concerning pharmacogenetics, the main features and their applications in oncology with a special focus on the possibility to exploit this information in the clinical settings in the near future. This topic will update about the main features of pharmacogenetics and their applications in oncology. In particular, this Research Topic will update about the effects of genetic variability on drug efficacy and toxicity, the identification and functional characterization of polymorphisms relevant to drug effect, the identification of new genetic targets for drug development and the clinical application of pharmacogenomics. We welcome Original research Articles, Systematic Reviews and Mini Reviews to be submitted.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
The response to treatment might be quite diverse within patients bearing solid tumors, mainly due to genetic factors. In order to define the key determinants of such heterogeneity and to design personalized schedules of treatment for each patient, it is of pivotal importance to study how genetic profile influences response to therapy. This is termed pharmacogenetics (or pharmacogenomics). In the latest years, improvements in molecular technologies such as microarrays, genotyping and high throughput DNA sequencing gave impulse to the broader use of pharmacogenetics. These approaches will possibly lead to the development of personalized drugs to treat cancer as well as other pathological conditions (Alzheimer disease, asthma, cardiovascular diseases and many more).
This Research Topic aims to update the currently available information concerning pharmacogenetics, the main features and their applications in oncology with a special focus on the possibility to exploit this information in the clinical settings in the near future. This topic will update about the main features of pharmacogenetics and their applications in oncology. In particular, this Research Topic will update about the effects of genetic variability on drug efficacy and toxicity, the identification and functional characterization of polymorphisms relevant to drug effect, the identification of new genetic targets for drug development and the clinical application of pharmacogenomics. We welcome Original research Articles, Systematic Reviews and Mini Reviews to be submitted.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.