New Insights Into Schizophrenia-Related Neural and Behavioral Phenotypes

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Background

We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Mental Health. Frontiers have organized a series of Research Topics to highlight the latest advancements in science in order to be at the forefront of science in different fields of research within Mental Health Research.

The Neuroscience portfolio at Frontiers is launching these Research Topics to promote international awareness of Mental Health Disorders. Over the past few decades, major progress has been made toward removing inequalities for people with Mental Health Disorders. However, in 2020, as the COVID-19 pandemic spread across the globe, a majority of countries announced lockdowns, impacting more than 90 percent of young people worldwide. Many people with Mental Health Disorders have been especially hard hit. Studies show that they have been disproportionately affected by increased loneliness, disruptions to routines, and services and support systems that they rely on.

This Research Topic article collection will focus on neuroscience research that can inform solutions for creating a culture of awareness, understanding, and solidarity, with this Topic focusing on neural and behavioural phenotypes associated with Schizophrenia

The Research Topic solicits brief, forward-looking contributions from researchers around the globe that describe the state of the art, outlining, recent developments and major accomplishments that have been achieved and that need to occur to move the field forward. Authors are encouraged to identify the greatest challenges in the sub-disciplines, and how to address those challenges.

The goal of this special edition Research Topic is to shed light on the progress made in the past decade in the field of Molecular Neuroscience and Schizophrenia and on its future challenges to provide a thorough overview of the status of the art of the Molecular Neuroscience field. This article collection will inspire, inform and provide direction and guidance to researchers in the field.

This topic focuses on, but is not limited to,

• Modelling mutations in mice, for example, generating Disc1tr transgenic mice expressing 2 copies of truncated Disc1 using a bacterial artificial chromosome (BAC).
. Human sample neuroimaging studies
. Human sample studies with non-invasive in vivo mapping techniques (like MRI) and computational models to explore brain-behavioral relationships
• Examining the range of phenotypes from these transgenic mutations.
• Investigating transgenic mice and reviewing previous studies that may show the effects of enlarged lateral ventricles, reduced cerebral cortex, partial agenesis of the corpus callosum, and thinning of layers II/III with reduced neural proliferation at midneurogenesis.
• Relating these findings above to schizophrenia behavioural phenotypes
• Investigating Parvalbumin GABAergic neurons that are reduced in the hippocampus and medial prefrontal cortex, and displaced in the dorsolateral frontal cortex.
• Reviewing why transgenic neurons grow fewer and shorter neurites.
• Behaviorally, why this can cause increased immobility and reduced vocalization in depression-related tests, and impairment in the conditioning of latent inhibition.
• Furthermore, the role of an MHC Enhancer Binding Proteins in schizophrenia such as deficiencies of Schnurri-2.

Keywords: schizophrenia, neural phenotypes, behavioural phenotypes

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

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