In the past few decades, the morbidity and mortality related to hepatitis B virus (HBV) have increased. HBV infection is the dynamic process of interactions among the hepatocytes, virus, and host immune system. In chronic HBV infection, the quantitative and functional deficiencies of virus-specific T cell responses are critical for the persistence of chronic infection. The control of Chronic hepatitis B (CHB) depends on the immune cells, such as dendritic cells (DCs), natural killer (NK) cells, CD4+ T lymphocytes, and CD8+ T lymphocytes, and cytokines released by those immune cells.
Therefore, in pregnant women with CHB, immune response defects are closely related to chronic infection. Postpartum liver dysfunction was common in women with chronic HBV infection, which may be dependent on the recovery of postpartum immune function after antiviral therapy.
However, in the pathogenesis of CHB, the role of many other immune cells and cytokines is still unclear, and the correlation of the immune cells and cytokines with antiviral therapy in pregnant women with chronic HBV infection remains unknown.
The goal of this Research Topic is to provide, mainly, but not solely, a forum to unveil the characteristics of these CHB patients’ immune profiles and the immune mechanisms during the onset of hepatitis, antiviral treatment, and pregnancy, with the aim to explore innovative intervention targets and possible clues for pathogenesis and antiviral treatment in patients with CHB infection.
The submission of Original Research and Review articles is welcome here including, but not limited to, the bullet points below:
1) Immunological mechanism of chronic hepatitis B;
2) T cell immune responses to antiviral treatment in chronic hepatitis patients;
3) Immunological characteristics of antiviral treatment in CHB patients;
4) NK cell immune responses to antiviral treatment in chronic hepatitis patients;
5) Immunological characteristics of postnatal hepatitis in CHB patients;
6) Immunological mechanisms of chronic hepatitis B in pregnancy;
7) Changes in immune cell phenotype, function, and related cytokines in HBV-infected pregnant women after delivery.
In the past few decades, the morbidity and mortality related to hepatitis B virus (HBV) have increased. HBV infection is the dynamic process of interactions among the hepatocytes, virus, and host immune system. In chronic HBV infection, the quantitative and functional deficiencies of virus-specific T cell responses are critical for the persistence of chronic infection. The control of Chronic hepatitis B (CHB) depends on the immune cells, such as dendritic cells (DCs), natural killer (NK) cells, CD4+ T lymphocytes, and CD8+ T lymphocytes, and cytokines released by those immune cells.
Therefore, in pregnant women with CHB, immune response defects are closely related to chronic infection. Postpartum liver dysfunction was common in women with chronic HBV infection, which may be dependent on the recovery of postpartum immune function after antiviral therapy.
However, in the pathogenesis of CHB, the role of many other immune cells and cytokines is still unclear, and the correlation of the immune cells and cytokines with antiviral therapy in pregnant women with chronic HBV infection remains unknown.
The goal of this Research Topic is to provide, mainly, but not solely, a forum to unveil the characteristics of these CHB patients’ immune profiles and the immune mechanisms during the onset of hepatitis, antiviral treatment, and pregnancy, with the aim to explore innovative intervention targets and possible clues for pathogenesis and antiviral treatment in patients with CHB infection.
The submission of Original Research and Review articles is welcome here including, but not limited to, the bullet points below:
1) Immunological mechanism of chronic hepatitis B;
2) T cell immune responses to antiviral treatment in chronic hepatitis patients;
3) Immunological characteristics of antiviral treatment in CHB patients;
4) NK cell immune responses to antiviral treatment in chronic hepatitis patients;
5) Immunological characteristics of postnatal hepatitis in CHB patients;
6) Immunological mechanisms of chronic hepatitis B in pregnancy;
7) Changes in immune cell phenotype, function, and related cytokines in HBV-infected pregnant women after delivery.
