Ferroptosis is a recently identified cell apoptosis catalysed by iron ions. It is intervened directly by the accumulation of lipid peroxides and reactive oxygen species (ROS). Positive regulation of ferroptosis provides a promising way for cancer therapy because of its ability to kill cancer cells. Inhibition of ferroptosis may offer a novel treatment for ferroptosis-related diseases, due to the improvement of cell survival. These diseases mainly include neurodegenerative diseases, liver diseases, cardiovascular diseases, blood cell-related diseases, infectious diseases, lung diseases, kidney diseases, and blinding diseases. Along with the aforementioned cancer diseases, a wide range of diseases may benefit from ferroptosis regulation.
Nowadays, medicinal chemists have screened several synthetic regulators, including Ferrostatin-1 (Fer-1), liproxstatin-1 (Lip-1), PKUMDL-LC-101, and UAMC-3203. These regulators comprise aromatic N-atom, which is incompatible with human cells; Especially, the latter two even present sulphanilamide structure which has been proven to be cytotoxic.
Searching for safe ferroptosis regulators from natural medicines has become a hot pursuit these days. Research on natural products modulating ferroptosis has often focused on dietary plants. These natural medicines usually have a long history of use in the prevention and treatment of various diseases. Their clinical or pharmacological effects are presumed to be associated with ferroptosis regulation. However, the chemical component, biological mechanism, and pharmacological mechanism remain unknown until now. Therefore, this Research Topic attempts to collect new findings regarding natural medicines for ferroptosis regulations.
We, as guest editors, invite you to submit original research and review articles. All these articles must report the ferroptosis regulations by the natural medicines. Here the so-called “regulations” refer to positive regulation as well as negative regulation (inhibition). Pure compound derived from plant, animal, and microorganism natural products and extract from such sources are included in the Research Topic. The research models are required to be cell models or animal models. We invite MSs dealing with the following themes:
• Activity screening of ferroptosis regulation of preparations derived from herbal medicines and their metabolites
• Ferroptosis regulation mechanisms of natural medicines
• Structure-activity relationship analysis of pure natural products (metabolites) in ferroptosis regulation
• Comparison study between natural products and synthetic compounds targeting in ferroptosis regulation
• Assessment of highly activity extracts from herbal medicines and their metabolites
• High-quality review article on ferroptosis regulation based on herbal medicines and their metabolites
It should be noted that:
• the ferroptosis regulation mechanisms refer to the biochemical or biological mechanism.
• the high activity extracts must be well characterized using chemical approaches, such as HPLC and HPLC-MS. The chemical characterization should be based on highly purified compounds.
• whenever a complex mixture is used, attempts need to me made to identify potentially active metabolites.
• purely in silico studies on supposed actions of crude extracts and/or mixtures are not within the scope.
All manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).
Ferroptosis is a recently identified cell apoptosis catalysed by iron ions. It is intervened directly by the accumulation of lipid peroxides and reactive oxygen species (ROS). Positive regulation of ferroptosis provides a promising way for cancer therapy because of its ability to kill cancer cells. Inhibition of ferroptosis may offer a novel treatment for ferroptosis-related diseases, due to the improvement of cell survival. These diseases mainly include neurodegenerative diseases, liver diseases, cardiovascular diseases, blood cell-related diseases, infectious diseases, lung diseases, kidney diseases, and blinding diseases. Along with the aforementioned cancer diseases, a wide range of diseases may benefit from ferroptosis regulation.
Nowadays, medicinal chemists have screened several synthetic regulators, including Ferrostatin-1 (Fer-1), liproxstatin-1 (Lip-1), PKUMDL-LC-101, and UAMC-3203. These regulators comprise aromatic N-atom, which is incompatible with human cells; Especially, the latter two even present sulphanilamide structure which has been proven to be cytotoxic.
Searching for safe ferroptosis regulators from natural medicines has become a hot pursuit these days. Research on natural products modulating ferroptosis has often focused on dietary plants. These natural medicines usually have a long history of use in the prevention and treatment of various diseases. Their clinical or pharmacological effects are presumed to be associated with ferroptosis regulation. However, the chemical component, biological mechanism, and pharmacological mechanism remain unknown until now. Therefore, this Research Topic attempts to collect new findings regarding natural medicines for ferroptosis regulations.
We, as guest editors, invite you to submit original research and review articles. All these articles must report the ferroptosis regulations by the natural medicines. Here the so-called “regulations” refer to positive regulation as well as negative regulation (inhibition). Pure compound derived from plant, animal, and microorganism natural products and extract from such sources are included in the Research Topic. The research models are required to be cell models or animal models. We invite MSs dealing with the following themes:
• Activity screening of ferroptosis regulation of preparations derived from herbal medicines and their metabolites
• Ferroptosis regulation mechanisms of natural medicines
• Structure-activity relationship analysis of pure natural products (metabolites) in ferroptosis regulation
• Comparison study between natural products and synthetic compounds targeting in ferroptosis regulation
• Assessment of highly activity extracts from herbal medicines and their metabolites
• High-quality review article on ferroptosis regulation based on herbal medicines and their metabolites
It should be noted that:
• the ferroptosis regulation mechanisms refer to the biochemical or biological mechanism.
• the high activity extracts must be well characterized using chemical approaches, such as HPLC and HPLC-MS. The chemical characterization should be based on highly purified compounds.
• whenever a complex mixture is used, attempts need to me made to identify potentially active metabolites.
• purely in silico studies on supposed actions of crude extracts and/or mixtures are not within the scope.
All manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).
