Promoting Nervous System Regeneration by Treatments Targeting Neuron-Glia Interactions

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Background

The field of regenerative medicine for neurological disorders has grown considerably in the past 30-40 years. Preclinical studies have revealed the primary cellular and molecular changes in neurons and glial cells from the peripheral nervous system (PNS) and central nervous system (CNS) in many neurological diseases and traumatic injuries. The knowledge acquired from those studies has helped scientists design therapies to rescue neurons and modulate glial cells response for various nervous system disorders with the aim of reaching functional recovery. Different therapeutic strategies – ranging from pharmacological to gene therapy, and electronic bridges – have shown to be efficacious in promoting neuroprotection and in some cases also inducing regeneration, modest functional recovery, or activating neuronal circuitry. More recently, studies have tried to address combinatorial treatments that target both neurons and glial cells to try and reach a more integrative recovery that potentially can lead to complete functional recovery.

Most of the studies that investigate disorders of the nervous system generally focus on either neuronal death or glial response, however, little is known about how those cells interact during the healing process and what mechanisms triggered by those interaction might be beneficial or detrimental to neuroprotection and regeneration of the nervous system. The aim of this Research topic is to bring together preclinical studies that investigate neuron-glia targeted therapies. Therefore, this research topic will help develop a body of evidence that will advance the field of regenerative medicine for the nervous system. We encourage researchers, from all disciplines, to share research updates and preclinical studies to increase our understanding of the field of regenerative medicine for CNS and PNS disorders.

Most of the studies that investigate disorders of the nervous system generally focus on either neuronal death or glial response, however, little is known about how those cells interact during the healing process and what mechanisms triggered by those interaction might be beneficial or detrimental to neuroprotection and regeneration of the nervous system.

The aim of this Research topic is to bring together preclinical studies that investigate neuron-glia targeted therapies. Therefore, this research topic will help develop a body of evidence that will advance the field of regenerative medicine for the nervous system. We encourage researchers, from all disciplines, to share research updates and preclinical studies to increase our understanding of the field of regenerative medicine for CNS and PNS disorders.

Keywords: CNS Disorders, PNS Disorders, Cell Death, Axon Degeneration, Regeneration, Neuron-Glia Interaction, Gene Therapy

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