Perioperative stress, inflammatory mediators, infection, ischemia, hypoxia, and many other factors can induce perioperative organ dysfunction, such as acute lung injury, acute kidney injury, liver injury, and neurological system injury. Perioperative organ dysfunction is the main cause of perioperative death in children, especially in neonates and preterm infants. Observational and experimental studies have established that immune factors, induced by infections, ischemia, and stress, generally regulate perioperative organ dysfunction. It is noteworthy that although effective organ prevention, protection, and therapy strategies have been broadly studied, these research works have generally focused on adults, but not on neonates or preterm infants. Thus, studies exploring immune regulation, pathophysiological mechanisms, and different responses in neonates or preterm infants are needed for the development of the research area of perioperative organ dysfunction and protection in children.
This Research Topic encourages submissions of original research papers and reviews with a focus on clinical study and/or basic mechanisms of perioperative organ dysfunction. The specific aims are 1) to explore the impact of immune regulation in the development, phenotype, or severity of perioperative organ dysfunction in neonates and preterm infants; 2) to explore the different mechanisms between full-term/preterm neonates during perioperative organ dysfunction; 3) to explore potential therapeutic and effective organ protection strategies, which may help to mitigate organ dysfunction in future contexts.
We welcome submissions addressing, but not limited to, the following themes:
• Acute lung injury induced by perioperative infection, sepsis, and mechanical ventilation, which may lead to a significant difference in the prevalence and molecular mechanisms between different age groups such as neonates, full-term/preterm infants, adolescents, and adults.
• Acute kidney injury, liver injury, heart failure, or multiple organ failure, which may be induced by extracorporeal circulation or severe surgical diseases, where operations in preterm newborns tend to amount to a stronger injury in terms of stress compared to full-term neonates.
• The mechanisms of neurological system injury during operation, particularly in neonatal surgery, and protection strategies.
Perioperative stress, inflammatory mediators, infection, ischemia, hypoxia, and many other factors can induce perioperative organ dysfunction, such as acute lung injury, acute kidney injury, liver injury, and neurological system injury. Perioperative organ dysfunction is the main cause of perioperative death in children, especially in neonates and preterm infants. Observational and experimental studies have established that immune factors, induced by infections, ischemia, and stress, generally regulate perioperative organ dysfunction. It is noteworthy that although effective organ prevention, protection, and therapy strategies have been broadly studied, these research works have generally focused on adults, but not on neonates or preterm infants. Thus, studies exploring immune regulation, pathophysiological mechanisms, and different responses in neonates or preterm infants are needed for the development of the research area of perioperative organ dysfunction and protection in children.
This Research Topic encourages submissions of original research papers and reviews with a focus on clinical study and/or basic mechanisms of perioperative organ dysfunction. The specific aims are 1) to explore the impact of immune regulation in the development, phenotype, or severity of perioperative organ dysfunction in neonates and preterm infants; 2) to explore the different mechanisms between full-term/preterm neonates during perioperative organ dysfunction; 3) to explore potential therapeutic and effective organ protection strategies, which may help to mitigate organ dysfunction in future contexts.
We welcome submissions addressing, but not limited to, the following themes:
• Acute lung injury induced by perioperative infection, sepsis, and mechanical ventilation, which may lead to a significant difference in the prevalence and molecular mechanisms between different age groups such as neonates, full-term/preterm infants, adolescents, and adults.
• Acute kidney injury, liver injury, heart failure, or multiple organ failure, which may be induced by extracorporeal circulation or severe surgical diseases, where operations in preterm newborns tend to amount to a stronger injury in terms of stress compared to full-term neonates.
• The mechanisms of neurological system injury during operation, particularly in neonatal surgery, and protection strategies.