Metabolism is defined as the sum of biochemical processes in living organisms that produce or consume energy. Metabolic pathways occur within the cytosol and mitochondria of cells with the utilization of glucose, fatty acids, or amino acids, providing the majority of cellular energy within mammals. Metabolic pathways are not only there to support cell type and context-specific bioenergetic demands but also to play instructive roles with precise metabolic signaling functions that ultimately determine normal and pathological cell fate decisions. Broadly, metabolic disorders occur when the body produces too much or fails to produce enough essential nutrients required for normal metabolism to support cellular health and function. Disruption of these homeostatic states results in metabolic disorders such as diabetes and obesity. In addition, it increases the risk of developing other pathological conditions, such as cardiovascular disease, cancer, and neurodegenerative diseases. Therefore, expanding our knowledge of how disturbed metabolism affects disease could pave the way for novel therapeutic opportunities.
With recent advances in metabolomics and computational analysis, we have increasing evidence implicating metabolic pathways as critical cell fate and function regulators. However, the mechanistic understanding of how metabolic pathways are dynamically regulated during development and disease still needs further investigation. This Research Topic aims to explore the role of metabolic pathways in shaping cell fate and how their dysregulation is associated with the disease.
We welcome submissions covering (but not limited to) the following topics:
- Metabolic regulation of cell fate and function
- Dynamic regulation of metabolic pathways during development and disease
- Metabolites in signaling and disease
- Role of Mitochondria in integrating energy production, biosynthetic pathways, and signal transduction - Role of mitochondrial function and metabolic dysregulation in aging and the pathophysiological mechanisms underlying cancer, neurodegenerative diseases, inflammation, etc
Metabolism is defined as the sum of biochemical processes in living organisms that produce or consume energy. Metabolic pathways occur within the cytosol and mitochondria of cells with the utilization of glucose, fatty acids, or amino acids, providing the majority of cellular energy within mammals. Metabolic pathways are not only there to support cell type and context-specific bioenergetic demands but also to play instructive roles with precise metabolic signaling functions that ultimately determine normal and pathological cell fate decisions. Broadly, metabolic disorders occur when the body produces too much or fails to produce enough essential nutrients required for normal metabolism to support cellular health and function. Disruption of these homeostatic states results in metabolic disorders such as diabetes and obesity. In addition, it increases the risk of developing other pathological conditions, such as cardiovascular disease, cancer, and neurodegenerative diseases. Therefore, expanding our knowledge of how disturbed metabolism affects disease could pave the way for novel therapeutic opportunities.
With recent advances in metabolomics and computational analysis, we have increasing evidence implicating metabolic pathways as critical cell fate and function regulators. However, the mechanistic understanding of how metabolic pathways are dynamically regulated during development and disease still needs further investigation. This Research Topic aims to explore the role of metabolic pathways in shaping cell fate and how their dysregulation is associated with the disease.
We welcome submissions covering (but not limited to) the following topics:
- Metabolic regulation of cell fate and function
- Dynamic regulation of metabolic pathways during development and disease
- Metabolites in signaling and disease
- Role of Mitochondria in integrating energy production, biosynthetic pathways, and signal transduction - Role of mitochondrial function and metabolic dysregulation in aging and the pathophysiological mechanisms underlying cancer, neurodegenerative diseases, inflammation, etc