Degenerative osteoarthropathy occurred the articular cartilage degeneration injury, joint edge and subchondral bone reactive growth, which is caused by aging, obesity, strain, trauma, congenital joint abnormalities, joint deformities, environmental factors, etc. This disease is more common in the weight-bearing joints and more active joints of middle-aged and elderly people. In recent years, the genetic and epigenetics of bone and joint diseases were investigated with the rapid development of high-throughput sequencing technology, the genome, pharmacogenomics, proteome, metabolome, transcriptome, and single-cell sequencing were used to explore the pathogenesis and therapeutic targets of bone and joint diseases, delaying the progression of bone and joint diseases, and finding new diagnostic and treatment methods have always been the focus of bone and joint diseases.
The primary goal of this topic is to provide cutting-edge research in the field of genetics and epigenetics of bone and joint diseases, including genomics, proteomics, metabolomics, transcriptomics, multi-omics data, GWAS analysis, biomarkers, molecular mechanism, and the discovery of new gene associations.
This Research Topic welcomes the submission of bioinformatics analysis, clinical trials, cell and animal experiments, systematic reviews, and meta-analyses focused on, but not limited to, the following topics:
(1) Multi-omics data analysis (genomics, proteomics, metabolomics, and transcriptomics) of bone and joint diseases.
(2) Novel biomarkers in the pathogenesis of degenerative bone and joint disease.
(3) New genes diagnostic model of bone and joint diseases.
(4) Cell and animal models of bone and joint diseases.
(5) Genetic and epigenetic of environmental related bone and joint diseases.
Degenerative osteoarthropathy occurred the articular cartilage degeneration injury, joint edge and subchondral bone reactive growth, which is caused by aging, obesity, strain, trauma, congenital joint abnormalities, joint deformities, environmental factors, etc. This disease is more common in the weight-bearing joints and more active joints of middle-aged and elderly people. In recent years, the genetic and epigenetics of bone and joint diseases were investigated with the rapid development of high-throughput sequencing technology, the genome, pharmacogenomics, proteome, metabolome, transcriptome, and single-cell sequencing were used to explore the pathogenesis and therapeutic targets of bone and joint diseases, delaying the progression of bone and joint diseases, and finding new diagnostic and treatment methods have always been the focus of bone and joint diseases.
The primary goal of this topic is to provide cutting-edge research in the field of genetics and epigenetics of bone and joint diseases, including genomics, proteomics, metabolomics, transcriptomics, multi-omics data, GWAS analysis, biomarkers, molecular mechanism, and the discovery of new gene associations.
This Research Topic welcomes the submission of bioinformatics analysis, clinical trials, cell and animal experiments, systematic reviews, and meta-analyses focused on, but not limited to, the following topics:
(1) Multi-omics data analysis (genomics, proteomics, metabolomics, and transcriptomics) of bone and joint diseases.
(2) Novel biomarkers in the pathogenesis of degenerative bone and joint disease.
(3) New genes diagnostic model of bone and joint diseases.
(4) Cell and animal models of bone and joint diseases.
(5) Genetic and epigenetic of environmental related bone and joint diseases.
