The regulation of gene expression is a wide field expanding from transcriptional control to processes involved in RNA stability, mRNA-ribosome interactions and translational control. These processes are tightly controlled: a coordinated response between transcription and translation allows cells to respond, adapt and survive to their environment. Deregulation of any of these processes is known to be associated with a broad number of diseases, ranging from neurodegenerative disorders to cancers.
Whilst we have a clear picture of the basic mechanisms regulating transcription and translation, our understanding of the finer details involved in these processes remain elusive. Therefore, detailed mechanistic studies will not only broaden our understanding but also allow the development of new therapeutic strategies to control cell responses.
This Research Topic aims to expand our mechanistic knowledge of transcriptional and translational regulation. Potential topics include, but are not limited to, the following:
- Motifs in 5'UTR and 3'UTR mRNA regions affecting translation.
- Impact of stress on translational control.
- Novel mechanisms controlling initiation of transcription and translation.
- Insights on deregulation of transcription and translation during disease.
- Role of mRNA localisation on translational control.
- Insights on role of non-coding RNA and RNA modifications on translation.
We welcome submissions of Original Research, Methods, Review, Mini-Review and Brief Research Report articles.
The regulation of gene expression is a wide field expanding from transcriptional control to processes involved in RNA stability, mRNA-ribosome interactions and translational control. These processes are tightly controlled: a coordinated response between transcription and translation allows cells to respond, adapt and survive to their environment. Deregulation of any of these processes is known to be associated with a broad number of diseases, ranging from neurodegenerative disorders to cancers.
Whilst we have a clear picture of the basic mechanisms regulating transcription and translation, our understanding of the finer details involved in these processes remain elusive. Therefore, detailed mechanistic studies will not only broaden our understanding but also allow the development of new therapeutic strategies to control cell responses.
This Research Topic aims to expand our mechanistic knowledge of transcriptional and translational regulation. Potential topics include, but are not limited to, the following:
- Motifs in 5'UTR and 3'UTR mRNA regions affecting translation.
- Impact of stress on translational control.
- Novel mechanisms controlling initiation of transcription and translation.
- Insights on deregulation of transcription and translation during disease.
- Role of mRNA localisation on translational control.
- Insights on role of non-coding RNA and RNA modifications on translation.
We welcome submissions of Original Research, Methods, Review, Mini-Review and Brief Research Report articles.
