The innate immune system is an ancient way of the host to defend against microbial pathogens, which is highly conserved in many species. When pathogens invade the host cells, pathogen-associated molecular patterns (PAMPs) would be recognized by the host with pattern recognition receptors (PRRs), which activate innate immune response to defend against pathogens. However, pathogens have also developed various strategies to counteract host innate immunity over the years. Bacteria, viruses and parasites could interfere with innate immune recognition and immune response with specific strategies, like structural proteins. However, the detailed mechanisms of innate immune evasion remain to be further explored. These evasion mechanisms compromise the elimination of pathogens and contribute to related infectious diseases.
This research topic focuses on the innate immune evasion strategies of pathogens, including bacteria, viruses and parasites, aiming for elucidating the pathogenic mechanism and providing new insight into the therapeutic intervention of microbial infection.
We invite authors to submit Original Research Articles and Reviews on the following point of this topic.
• The interaction between PAMPs and PRRs.
• The counteraction of pathogens on innate immune response, including interferons, inflammation cytokines and so on.
• Functional impairment of innate immune cells during microbial infection, including NK Cells, Macrophages, Dendritic Cells and so on.
• Pathogenic mechanisms caused by innate immune evasion.
• New targets and therapies of microbial infection based on the mechanisms of innate immune evasion.
The innate immune system is an ancient way of the host to defend against microbial pathogens, which is highly conserved in many species. When pathogens invade the host cells, pathogen-associated molecular patterns (PAMPs) would be recognized by the host with pattern recognition receptors (PRRs), which activate innate immune response to defend against pathogens. However, pathogens have also developed various strategies to counteract host innate immunity over the years. Bacteria, viruses and parasites could interfere with innate immune recognition and immune response with specific strategies, like structural proteins. However, the detailed mechanisms of innate immune evasion remain to be further explored. These evasion mechanisms compromise the elimination of pathogens and contribute to related infectious diseases.
This research topic focuses on the innate immune evasion strategies of pathogens, including bacteria, viruses and parasites, aiming for elucidating the pathogenic mechanism and providing new insight into the therapeutic intervention of microbial infection.
We invite authors to submit Original Research Articles and Reviews on the following point of this topic.
• The interaction between PAMPs and PRRs.
• The counteraction of pathogens on innate immune response, including interferons, inflammation cytokines and so on.
• Functional impairment of innate immune cells during microbial infection, including NK Cells, Macrophages, Dendritic Cells and so on.
• Pathogenic mechanisms caused by innate immune evasion.
• New targets and therapies of microbial infection based on the mechanisms of innate immune evasion.