Ginsenosides are the most important group of metabolites of ginseng (
Panax ginseng C.A. Meyer), and it is also widely found in
Panax quinquefolius and
Panax notoginseng. Since the 1960s, their potential for a potential adjuvant anticancer activity has been investigated, and soon ginsenosides became a popular area of natural product research. The unique potential of natural products in the prevention and treatment of various complex diseases, especially chronic diseases, has attracted global attention. So far, ginsenosides have been shown to have a variety of powerful pharmacological activities, including the effects of anti-oxidation, anti-aging, anti-diabetes, and anti-tumor. However, there remains a need to carefully evaluate the potential activities of this class of metabolites, and the mechanism of ginsenoside remains only partially understood. Therefore, research on the potential pharmacological activities and therapeutic mechanisms of ginsenosides is important for the future clinical use of ginsenosides.
Recently, many new ginsenosides such as (20E), 25(OH)-ginsenoside Rg9, (20Z), 25(OH)-ginsenoside Rg9, and ginsenoside Rh26 have been discovered and their potential pharmacological activities need to be explored. The purpose of this series is to explore the ginsenosides’ potential pharmacological and pharmacokinetic properties as well as their clinical properties as adjuvant therapy. With this research topic, we hope to enrich the modern pharmacological research on ginsenosides and elucidate their potential mechanisms as much as possible.
We want to attract researchers working on the pharmacological activity of ginsenosides to submit their novel research on this important class of metabolites. We welcome both relevant original research and review articles. Potential topics include, but are not limited to, the following:
•Ginsenosides for multi-targeted disease therapy - pharmacological evaluation based on molecular biological function
•The pharmacokinetics of ginsenosides
•Recent progress on the ginsenosides and their activities
•Effects of ginsenosides on the central nervous system and its underlying molecular mechanisms
•Protective effects of ginsenosides on chemotherapy-induced toxicity
•Pharmacodynamic evaluation of ginsenosides as clinical adjuvant therapy including in the adjuvant therapy for cancer and related complications
•Coordinated protocols for the study of ginsenosides: the role of chemical analysis from in vitro to clinical studies.
•Interactions between ginsenosides and clinically used drugs: Pharmacodynamic and pharmacokinetic approaches
NOTE:
1. Clinical Trial articles will be accepted for review only if they are randomized, double-blinded, and placebo controlled. Statistical power analysis or a justification of the sample size is mandatory.
2. All submissions to the journal Frontiers in Pharmacology using plant extracts or preparations must also adhere to the
Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version
here to be considered for peer review. With such a well–studied group of metabolites, we draw the authors’ attention to the need for detailed chemical characterization of extracts used in any pharmacological or clinical study.