Recently, immune regulation is revealed to play critical roles in various diseases or progressions, such as tumors, cardiovascular disease, metabolic syndrome, and other disorders. Therefore, many studies had been performed to investigate its underlying mechanism, particularly in malignancies, and virus infection (COVID-19). The relationship between the immune microenvironment and cell death is an attractive field for scientists and clinicians.
Cell death commonly consists of regulated cell death (RCD) and accidental cell death (ACD). On one hand, the exogenous factors, including biochemical stress and overloaded physical temperature, may contribute to ACD. On the other hand, RCD, such as apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy, and cuproptosis, shows another effective way of cell death. With the progression of various cell death, many antigens, cytokines, and chemokines were released from cancer cells into the extracellular environment, and these stimulants would initiate and exaggerate immune response effectively. The consequence of that can enhance the efficacy of tumor immunotherapy. Moreover, the signature of the cell death-associated genes can be further used as diagnosed markers and therapeutic targets. Particularly, RCD had been shown to reconstruct the immune microenvironments, which further affect the progression of multiple disorders, indicating its critical role in the diagnosis and treatment of various diseases.
The goal of this research topic is to provide a forum to advance research on the contribution of pan-cell death (apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, cuproptosis, etc.) of tumor cells to the reconstruction of tumor immune microenvironment, which further influences the progression of various diseases. Additionally, these novel findings could be used to develop approaches for the diagnosis, treatment, and prognosis of cancer.
A Research Topic on “Roles of pan-cell death of tumor cells in regulating tumor immune microenvironment” welcome Original Research and Review articles, including the bullet points as below:
1) Mechanisms of pan-cell death in cancer cells;
2) Association between pan-cell death of tumor cells and immune cell infiltration;
3) Pan-cell death of tumor cells and neoantigen production, TCR diversity, MHC presentation;
4) Pathways of pan-cell death and prognostic model of cancers;
5) Impact of pan-cell death of tumor cells on cancer immunotherapy;
6) Cancer biotherapy (gene therapy, cell therapy, mRNA, peptides, etc.) targeting pan-cell death pathway;
8) Nanomedicine for cancers based on pan-cell death pathways;
9) Comparative or combined studies of pan cell death of tumor cells (apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, cuproptosis, etc) in cancers;
10) Cell origin of different cell death patterns.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Recently, immune regulation is revealed to play critical roles in various diseases or progressions, such as tumors, cardiovascular disease, metabolic syndrome, and other disorders. Therefore, many studies had been performed to investigate its underlying mechanism, particularly in malignancies, and virus infection (COVID-19). The relationship between the immune microenvironment and cell death is an attractive field for scientists and clinicians.
Cell death commonly consists of regulated cell death (RCD) and accidental cell death (ACD). On one hand, the exogenous factors, including biochemical stress and overloaded physical temperature, may contribute to ACD. On the other hand, RCD, such as apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy, and cuproptosis, shows another effective way of cell death. With the progression of various cell death, many antigens, cytokines, and chemokines were released from cancer cells into the extracellular environment, and these stimulants would initiate and exaggerate immune response effectively. The consequence of that can enhance the efficacy of tumor immunotherapy. Moreover, the signature of the cell death-associated genes can be further used as diagnosed markers and therapeutic targets. Particularly, RCD had been shown to reconstruct the immune microenvironments, which further affect the progression of multiple disorders, indicating its critical role in the diagnosis and treatment of various diseases.
The goal of this research topic is to provide a forum to advance research on the contribution of pan-cell death (apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, cuproptosis, etc.) of tumor cells to the reconstruction of tumor immune microenvironment, which further influences the progression of various diseases. Additionally, these novel findings could be used to develop approaches for the diagnosis, treatment, and prognosis of cancer.
A Research Topic on “Roles of pan-cell death of tumor cells in regulating tumor immune microenvironment” welcome Original Research and Review articles, including the bullet points as below:
1) Mechanisms of pan-cell death in cancer cells;
2) Association between pan-cell death of tumor cells and immune cell infiltration;
3) Pan-cell death of tumor cells and neoantigen production, TCR diversity, MHC presentation;
4) Pathways of pan-cell death and prognostic model of cancers;
5) Impact of pan-cell death of tumor cells on cancer immunotherapy;
6) Cancer biotherapy (gene therapy, cell therapy, mRNA, peptides, etc.) targeting pan-cell death pathway;
8) Nanomedicine for cancers based on pan-cell death pathways;
9) Comparative or combined studies of pan cell death of tumor cells (apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, cuproptosis, etc) in cancers;
10) Cell origin of different cell death patterns.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
